Speakers: Frank Slack (Yale University), Ramanjulu Sunkar (Oklahoma State University), Evgeny Nudler (New York University), Anthony Leung (Massachusetts Institute of Technology), Irina Groisman (André Lwoff Institute), Germano Cecere (Columbia University)Presented by the Non-coding RNA Biology Discussion GroupReported by Don Monroe | Posted October 13, 2009
Overview
Since the 1990s, researchers have recognized a growing number of ways in which naturally occurring short RNAs regulate aspects of gene expression, both in normal processes like development and in diseases like cancer. On May 12, 2009, the Academy's Non-coding RNA Biology Discussion Group gathered to explore how these endogenous RNAs affect stress responses and longevity.
Speakers discussed a variety of small RNAs and their roles in determining lifespan, focusing on work in Drosophila, C. elegans, mice, and plants. Topics included recent research on how microRNAs could be used as biomarkers in aging; the role of endogenous small RNAs in plant stress responses; how small RNAs function in heat shock response in eukaryotes; the function of the polymer poly(ADP-ribose) in regulating activity of RNA and RNA-binding proteins in stress granules; and how microRNAs regulate cell senescence.
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