• Academy Events

  • Targeting Metals in Alzheimer's and Other Neurodegenerative Diseases

    Thursday, November 29, 2012 | 12:00 PM - 4:15 PM
    The New York Academy of Sciences

    Presented by the Brain Dysfunction Discussion Group at the New York Academy of Sciences

    Related Content

    Alzheimer's disease (AD) is characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral β-amyloid deposits. Both ionic zinc and copper accelerate the aggregation of Aβ, the principle component of β-amyloid deposits. Copper and iron can also promote the neurotoxic redox activity of Aβ and induce oxidative cross-linking into stable oligomers. Recent reports documented the release of Aβ together with ionic zinc and copper in cortical glutaminergic synapses following excitation, leading to the formation of Aβ oligomers. Excessive accumulation of Aβ oligomers in the synaptic cleft is thought to adversely affect synaptic neurotransmission, and transition metals have been implicated in the misfolding and accumulation of a-synuclein and Huntington protein in Parkinson's and Huntington's diseases (PD and HD), respectively, as well as tau hyperphosphorylation in AD, contributing to disease pathogenesis and progression. The "Metal Hypothesis of Neurodegenerative Diseases" is proposed to describe the underlying, possibly causative, events, leading to the neuropathology that drives AD, PD, and HD. This symposium examines how these findings led to the discovery of small molecules designed to restore the physiologic balance of transition metals in the brain, prevent further accumulation of misfolded proteins, and possibly even have a disease-modifying effect. A review of the early clinical experience of one such compound, PBT2, will be presented.

    *Networking reception to follow event.

    This event will also be broadcast as a webinar; registration is required.

    Please note: Transmission of presentations via the webinar is subject to individual consent by the speakers. Therefore, we cannot guarantee that every speaker's presentation will be broadcast in full via the webinar. To access all speakers' presentations in full, we invite you to attend the live event in New York City where possible.

    Registration Pricing

    Member $0
    Student/Postdoc Member $0
    Nonmember $40
    Nonmember (Student / Postdoc / Resident / Fellow) $20


    The webinar is free, but registration is required.

    Webinar & eBriefing Sponsor

    • Prana Bio

    The Brain Dysfunction Discussion Group is proudly supported by

    Mission Partner support for the Frontiers of Science program provided by Pfizer