|
In 1997, a new disease was recognized among patients with pre-existing renal dysfunction. Now known as Nephrogenic Systemic Fibrosis (NSF), the disorder is known to be highly associated with, and very likely triggered by, gadolinium based magnetic resonance imaging contrast agents (GBCA). As such, it is a man-made disease, very likely a hitherto uncharacterized fibrosing toxicity to heavy metal deposition in the human body. Much of what we know about NSF stems from the NSF Registry at Yale University, and, in recent years, an annual scientific meeting on NSF hosted at Yale.
The May 2010 Fourth Annual Meeting on NSF and GBCA will have several goals. As the 4th meeting represents a change in venue from New Haven, CT to New York City, a very important aspect will be introducing the disease to a new, and much larger community of practitioners and scientists, chiefly in nephrology, radiology, rheumatology, dermatology and pathology. The introductory sessions will provide the historical context of NSF—how it was discovered, the mechanics of how it is diagnosed, and the significance of gadolinium micro-detection. The core of the meeting will focus on the mechanism of fibrosis in NSF—these derived from animal and tissue culture studies. The discussion will be broadened to include known mechanisms of tissue fibrosis (systemic and organ specific) and potential targets of pharmacologic therapy. Lastly, we will examine the lessons learned from NSF: the current state of prevention, and practical strategies for using GBCA wisely in those at risk.
Overall, the breadth of discussions will extend from the cells and atoms responsible for NSF to the entire population at risk, and therapeutically and mechanistically from the scientific bench-top to the bedside. Of greater importance, perhaps, is the impact this work will have on the fundamental understanding of fibrosis in general, opening up new avenues of understanding into disease mechanisms previously thought to be unchallengeable by medicine.
For more information about this symposium, please go to the Yale CME website.
Call for Abstracts
The deadline for abstract submissions is Friday, March 12, 2010. For complete abstract instructions, please e-mail: NSF@nyas.org. Type the words "Abstract Information" in the subject line - there is no need to type a message. Instructions will be forwarded automatically. Any questions, please call 212.298.8611.
Organizers
Ali K. Abu-Alfa
Yale Medical School
Shawn Cowper
Yale Medical School
Learning Objectives
Participants who attend this conference will be able to:
- • Receive updated information on the diagnosis and treatment of NSF.
- • Review current understanding of the pathophysiology of NSF .
- • Recognize important differences among the various GBCA.
- • Discuss the impact on patient care and practice management.
- • Discuss strategies to identify patients with kidney disease who might be at risk.
Accreditation Statement
The Yale School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The American Medical Association has determined that physicians not licensed in the US who participate in this CME activity are eligible for AMA PRA Category 1 Credit™.
Designation Statement
The Yale School of Medicine designates this educational activity for a maximum of 12 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Disclosure Policy
It is the policy of Yale School of Medicine, Continuing Medical Education, to ensure balance, independence, objectivity and scientific rigor in all its educational programs. All faculty participating as speakers in these programs are required to disclose any relevant financial relationship(s) they (or spouse or partner) have with a commercial interest that benefits the individual in any financial amount that has occurred within the past 12 months; and the opportunity to affect the content of CME about the products or services of the commercial interests. The Center for Continuing Medical Education will ensure that any conflicts of interest are resolved before the educational activity occurs.
Presented by
*Image kindly donated by Shawn Cowper: Heart muscle (red) entwined in fibrous collagen (blue) from a young NSF patient (Trichrome stain)
Agenda
Friday, May 14, 2010
|
| 12:00 PM |
Registration
|
| 12:30 PM |
Welcome Ali Abu-Alfa MD, FASN, Yale School of Medicine Shawn Cowper, MD, The International Center for Nephrogenic Fibrosing Dermopathy Research
|
Session I
Moderator: TBA
|
| 12:40 PM |
Nephrogenic Systemic Fibrosis: Definition, Systemic Effects and Disease Course Shawn Cowper, MD, The International Center for Nephrogenic Fibrosing Dermopathy Research
|
| 1:10 PM |
Nephrogenic Systemic Fibrosis and GBCA: Radiology Revelations Emanuel Kanal, MD, University of Pittsburgh Medical Center
|
| 1:40 PM |
Update on Gleevec Treatment in NSF Jonathan Kay, MD, University of Massachusetts Medical School
|
| 2:10 PM |
Refreshment Break & Poster Reviews
|
| 2:30 PM |
Detection of Gadolinium in Tissues: What does it Mean, Exactly? Whitney A. High, MD
|
| 3:00 PM |
NSF and GBCA: Pharmacovigilance and Regulatory Actions in the US TBD
|
| 3:30 PM |
Q&A
|
| 4:00 PM |
Platform Presentations Moderator: Phillip H. Kuo MD, PhD, University of Arizona School of Medicine
|
| 5:00 PM |
Break
|
Keynote Lecture
|
| 5:15 PM |
The Discovery of NSF Philip Leboit, MD, University of California, San Francisco
|
| 5:45 PM |
Reception
|
Saturday, May 15, 2010
|
| 7:30 AM |
Registration and Continental Breakfast
|
Session II
Moderator: TBD
|
| 8:30 AM |
The Pathophysiology of Fibrosis Jack Gauldie, PhD, McMaster University
|
| 9:10 AM |
The Role of Endothelin-I in Fibrosis Kevin K. Brown, MD, University of Colorado
|
| 9:30 AM |
The Role of Osteopontin in Fibrosis Susanne Nicholas, MD, PhD, David Geffen School of Medicine at UCLA
|
| 9:50 AM |
GBCA and the Induction of Matrix Production Michael Edwards, PhD
|
| 10:10 AM |
Refreshment Break & Poster Viewing
|
| 10:30 AM |
Impact of GBCA on Fibrocyte Function Richard Bucala, MD, PhD, Yale School of Medicine
|
| 11:00 AM |
Fibrosis Roundtable Moderator: TBD Panel: • Kevin K. Brown, MD, Univeristy of Colorado • Richard Bucala, MD, PhD, Yale School of Medicine • Michael Edwards, PhD • Susanne Nicholas, MD, PhD, David Geffen School of Medicine at UCLA
|
Session III: Part 1
Gadolinium: Its Theoretical and Observed Effects in vivo - Models and Their Validity: Physicochemical Properties of GBCAs and the Link to NSF Moderator: Ali Abu-Alfa MD, FASN, Yale School of Medicine Co-Moderator: Michael Girardi, MD
|
| 11:30 AM |
Title TBD John Haylor, PhD, University of Colorado School of Medicine Sameh K. Morcos, MD, University of Sheffield
|
| 11:45 AM |
Title TBD Thomas Hope, MD, University of California, San Francisco
|
| 12:00 PM |
Lunch
|
Session III: Part 2
Gadolinium: Its Theoretical and Observed Effects in vivo - Models and Their Validity: Physicochemical Properties of GBCAs and the Link to NSF Moderator: Ali Abu-Alfa MD, FASN, Yale School of Medicine Co-Moderator: Michael Girardi, MD (*Note: CME credit is not available during this session.)
|
| 1:00 PM |
Title TBD Jean-Marc Idee, MS, PharmD
|
| 1:15 PM |
Title TBD Hubertus Pietsch, DVM, Bayer-Schering Pharamceuticals Martin Sieber, PhD, Bayer-Schering Pharmaceuticals
|
| 1:30 PM |
Title TBD Derek Grant, PhD, GE Healthcare
|
| 1:45 PM |
Title TBD April Cox, MS, Array Biopharma
|
| 2:00 PM |
Panel Discussion Moderators: Ali Abu-Alfa MD, FASN & Michael Girardi MD
|
| 2:30 PM |
Refreshment Break & Poster Defense
|
SESSION IV: Patient and Provider Perspectives on Specific Disease Areas
Moderator: Jeff Weinreb, MD, Yale School of Medicine
|
| 3:15 PM |
Approach to the Use of GBCA in Patients with Kidney Disease Ali Abu-Alfa, MD, FASN, Yale School of Medicine
|
| 4:00 PM |
Panel Discussion - Controversies in the Continued Use of GBCAs Moderator: Jeffrey Weinreb, MD, Yale School of Medicine
Panel: • Ali Abu-Alfa, MD, FASN, Yale School of Medicine • Peter Marckmann, MD, Copenhagen Univeristy of Hospital • Sameh K. Morcos, MD, Univeristy of Sheffield • Martin Prince, MD, PhD, New York Hospital • Henrik Thomsen, MD, Copenhagen University Hospital
|
| 5:15 PM |
Closing Statements Ali Abu-Alfa, MD, FASN, Yale School of Medicine Shawn Cowper, MD, The International Center for Nephrogenic Fibrosing Dermopathy Research
|
| 5:30 PM |
Adjourn
|
Supporters
For opportunities to support this event, please contact Deborah Dunn at deborah.dunn@yale.edu or 203.785.4578.
Presented by
Academy Friends
- • This event is funded in part by the Life Technologies™ Foundation.
Travel & Lodging
Our Location
The New York Academy of Sciences
7 World Trade Center 250 Greenwich Street, 40th floor New York, NY 10007-2157 212.298.8600
Click here for directions.
Hotels Near 7 World Trade Center
Recommended partner hotel:
Club Quarters, World Trade Center
140 Washington Street New York, NY 10006 Phone: (212) 577-1133
Located on the south side of the World Trade Center, opposite Memorial Plaza, Club Quarters, 140 Washington Street, is just a short walk to our location. The New York Academy of Sciences is a part of the Club Quarters network. Please feel free to make accommodations on-line to save significantly on hotel costs.
Password: NYAS
Other hotels located near 7 WTC:
|
|