Species differences in pharmacological response exist and are well known. Yet it remains common practice to select and advance compounds to clinical trials based upon gross pharmacological responses observed in animals. Not surprisingly, safety and efficacy findings that fail to translate from preclinical models account for most of the unacceptably high rate of attrition currently experienced by the pharmaceutical industry. This challenge has largely served as the impetus for emerging translational research efforts. Pharmacokinetic-pharmacodynamic (PK-PD) modeling and systems pharmacology are essential tools in the translational research toolkit for the systematic, quantitative integration of diverse preclinical information for the sake of rational drug design, candidate selection and development. In this symposium, experts from both areas of practice will review guiding principles, general considerations and specific applications in quantitative translational research.
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