This volume consists of reviews that cover a range of subjects, with authorship from the United States and European Union. The likely inclusion of craving in DSMV criteria for addiction confer special timeliness on the paper from Stephen Tiffany. We can now look back on both addiction therapeutics, in general, and on a clinically- and financially successful antiaddiction medication, buprenorphine, in the papers from Nancy Campbell, Anne Lovell, Ed Johnson, Christian Heidebreder and their colleagues. Marcus Munafo provides an important emphasis of the ways in which socioeconomic status interacts with a common addiction, smoking. Ivy Caroll provides an excellent update on the medicinal chemistry of new designer drugs that proves his uncanny ability to trace designed drugs from the streets back to the papers in which their syntheses and properties were described. The often-underappreciated role of ultrastructural information in defining circuits important for addiction is reviewed by longtime leaders in this field, Mariscella Morales and Virginia Pickel. The important continuing contributions of smoking comorbidities are reviewed by Tony George and colleagues, and a framework for mouse models for smoking cessation advanced in the review by Hall, Uhl and colleagues. Danielli Piomelli ably summarizes the field of cannabinoids based on his longstanding work in this area. Piazza and colleagues provide an updated theoretical approach to models for addiction. Taken together, these papers aim for timeliness and summaries of fields that are likely to become classics.

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