A Systems Approach to Metabolic Health
Keynote Speaker: Frank Hu (Harvard T.H. Chan School of Public Health)
This eBriefing explores research on metabolic health from several disciplines and looks at how different types of data combine to explain physiology and disease.
In this eBriefing
- A systems approach to disease prevention and metabolic health
- Data analysis to untangle the causes of metabolic disorders
- Models to inform public policy and debate
June 30, 2015
Keynote Speaker: Frank Hu (Harvard T.H. Chan School of Public Health)
Systems-based approaches to nutrition research can elucidate the complex ways nutrition influences chronic diseases. This eBriefing explores research on metabolic health from several disciplines and looks at how different types of data combine to explain physiology and disease.
May 29, 2015
Keynote Speakers: Miia Kivipelto (Karolinska Institute, Sweden), Irwin H. Rosenberg (Tufts University), and A. David Smith (University of Oxford, UK)
This eBriefing discusses epidemiological evidence for the role of diet in cognitive function and looks at nutritional and lifestyle strategies to delay or prevent dementia.
April 28, 2015
Moderator: Bamini Jayabalasingham (Association for Women in Science; City University of New York)
Speakers: Kelly Mack (Association of American Colleges & Universities), Sandra K. Masur (Icahn School of Medicine at Mount Sinai), Beth McCormick (Pfizer), and Eric Sweet (Icahn School of Medicine at Mount Sinai; NY Citywide Postdoc Council)
Panelists discussed the effectiveness of policy initiatives that aim to support gender balance in STEM fields.
March 24, 2015
Speakers: Susan D. Croll (Regeneron), Uzi de Haan (Cornell Tech), and Karen Hanson Widbin (Pfizer)
This eBriefing looks at nontraditional postdoctoral tracks in drug discovery and applied research, considering the structure of postdoc programs in industry and opportunities for innovation and creativity.
March 5, 2015
Organizers: Magdalena Alonso-Galicia (MAG Pharma Consulting LLC), Ken Jones (Allergan), Scott MacDonnell (Boehringer Ingelheim Pharmaceuticals), and Jennifer Henry (formerly at The New York Academy of Sciences)
With a poor understanding of its pathogenesis and few biomarkers, identifying and prosecuting drug targets for diabetic kidney disease is challenging. This eBriefing reviews targets for preventive or therapeutic interventions and discusses clinical development.
March 3, 2015
Organizers: Cynthia Duggan (The New York Academy of Sciences), Maike Stenull (Johnson & Johnson), and George Vradenburg (Global CEO Initiative on Alzheimer's Disease)
Keynote Speaker: Dennis Gillings (World Dementia Council)
This eBriefing explores new public and private funding mechanisms to meet the challenges of financing AD research and care. It considers several investment models and policy initiatives and looks at how best to apply government funds.
February 6, 2015
Keynote Speakers: Robert E. Brackett (Illinois Institute of Technology) and Frank Yiannas (Wal-Mart Stores Inc.)
This eBriefing considers issues of food security, economics, policy, and communication related to food safety.
January 30, 2015
Speakers: Maureen M. Black (University of Maryland School of Medicine), Edward A. Frongillo (University of South Carolina), Michael K. Georgieff (University of Minnesota), and Betsy Lozoff (University of Michigan)
This eBriefing highlights research on nutrition and brain development presented at the Fifth Annual Aspen Brain Forum.
January 30, 2015
Keynote Speaker: Thomas R. Insel (National Institute of Mental Health, NIH)
In early life, massive changes take place in the connectivity and plasticity of the brain that determine the future success of a child. This eBriefing explores cognitive neuroscience research on early development; social, family, and nutritional factors that cause lasting changes in the brain; and intervention, education, and policy initiatives to help at-risk children.
December 19, 2014
Keynote Speaker: The Honorable Patrick J. Kennedy (Former U.S. Representative, Rhode Island; One Mind for Research; Kennedy Forum)
This eBriefing explores the translation of neuroscience breakthroughs into therapies for mental illness. A keynote lecture looks at strategies to dispel stigma surrounding mental illness so that new treatments are accessible to all.
December 16, 2014
Organizers: John G. Kral (SUNY Downstate Medical Center), Michael Gibney (University College Dublin), Blandine Laferrère (Columbia University), Andrew G. Swick (Metagenics), Karen Teff (National Institutes of Health), Mandana Arabi (The Sackler Institute for Nutrition Science), and Amy Beaudreault (The Sackler Institute for Nutrition Science)
This eBriefing examines obesity risks that occur in early life and considers how to intervene to prevent and treat diabesity and related diseases. Topics include maternal nutrition, genetics, the microbiome, metabolic disorders, fetal development, generational effects, and early diet.
December 9, 2014
Speaker: Jaime S. Rubin (Columbia University)
This eBriefing reviews grant writing at the graduate and postdoctoral levels, focusing on how to apply for research grants in the sciences, where to find resources, and how to avoid common mistakes.
November 21, 2014
Organizers: Peng Wu (Albert Einstein College of Medicine) and Jennifer Henry (formerly at The New York Academy of Sciences)
Keynote Speakers: Jim Paulson (Scripps Research Institute) and K. Barry Sharpless (Scripps Research Institute)
Click chemistry mimics the simplicity of reactions found in nature for synthesizing large complex molecules, proceeding via the stepwise addition of small building blocks with minimal toxic byproducts. This eBriefing explores recent developments in the search for click reactions with applications in disease diagnosis and therapy.
November 12, 2014
Organizers: John A. Allen (Pfizer), Mercedes Beyna (Pfizer), Bryan L. Roth (University of North Carolina School of Medicine), and Jennifer Henry (formerly at The New York Academy of Sciences)
This eBriefing looks at how to exploit biased ligand signaling at GPCRs to improve therapeutics for cardiovascular and CNS disorders. GPCRs signal via canonical pathways involving G proteins and via other signaling proteins, including β-arrestins. Discovering ligands with the desired signaling bias enables beneficial efficacy while reducing side effects.
November 5, 2014
Featured Speakers: Emmanuelle Charpentier (Helmholtz Centre for Infection Research, Hannover Medical School, Germany; Umeå University, Sweden) and Jennifer Doudna (University of California, Berkeley; Howard Hughes Medical Institute)
This eBriefing features Emmanuelle Charpentier and Jennifer Doudna, recipients of the 2014 Dr. Paul Janssen Award for Biomedical Research for their role in understanding and adapting the CRISPR/Cas system for genome editing. Applications of the technique in human disease research and therapy are also described.
October 14, 2014
Organizers: C. Thomas Caskey (Baylor College of Medicine), Brian Clark (University of Aarhus, Denmark), Gregory A. Petsko (Weill Cornell Medical College), and Jennifer Henry (formerly at The New York Academy of Sciences)
The identification of the genetic code has offered many opportunities for further scientific discovery. This eBriefing documents a symposium that honored the legacy of Nobel laureate Marshall Nirenberg and showcased research in a range of therapeutic areas.
September 5, 2014
Keynote Speaker: Robin Franklin (Wellcome Trust – MRC Cambridge Stem Cell Institute, University of Cambridge)
This eBriefing highlights biological and clinical findings in remyelination and repair in genetic, inflammatory, infectious, cerebrovascular, and neurodegenerative conditions and injuries. It also features new techniques for imaging myelin changes in the brain and for screening molecular targets, as well as emerging therapeutics that promote remyelination.
August 12, 2014
Speakers: James P. Allison (University of Texas MD Anderson Cancer Center), Charles A. Dinarello (University of Colorado–Denver), and John J. O'Shea (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH)
This eBriefing features John J. O'Shea, recipient of the 2014 Ross Prize in Molecular Medicine for his discoveries in immunology and cytokine biology. Recent research on therapies targeting cytokine signaling in autoimmune and inflammatory diseases and checkpoint modulators in cancer is also described.
July 17, 2014
Organizers: Howard Fillit (Alzheimer's Drug Discovery Foundation), Kevin J. Lee (Lawrence Ellison Foundation), and Jennifer Henry (The New York Academy of Sciences)
Age is the major risk factor for Alzheimer's disease, and key pathways in aging biology offer targets for novel drugs. This eBriefing explores advances in the science of aging and in drug discovery for Alzheimer's and other neurodegenerative diseases.
July 15, 2014
Organizers: Chris Beyrer (Johns Hopkins Bloomberg School of Public Health), Peter Godfrey-Faussett (UNAIDS), Ani Shakarishvili (UNAIDS), Yegor Voronin (Global HIV Vaccine Enterprise), and Jennifer Henry (The New York Academy of Sciences)
The UNAIDS vision of zero new HIV infections, zero AIDS-related deaths, and zero discrimination calls for a global approach to HIV research and policy. This eBriefing focuses on improving outcomes for HIV in key vulnerable populations.