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  • Academy eBriefings

  • eBriefing

    Advances in Human Microbiome Science: Gut–Brain Interaction

    Organizers: John Hambor (Boehringer Ingelheim), Sarkis Mazmanian (California Institute of Technology), Nilufer Seth (Pfizer), Erick Young (Boehringer Ingelheim), Sonya Dougal (The New York Academy of Sciences), and Caitlin McOmish (The New York Academy of Sciences)

    This eBriefing discusses gut–brain interactions and the possibility of targeting the microbiome with a focus on CNS health.

    In this eBriefing

    • Causal relationships between microbiota and disease: microbiome–gut–brain axis
    • Gut microbiota, mental health, and psychiatric disorders
    • Mechanisms and possible interventions in gut–brain networks
  • Recent eBriefings 

    May 26, 2016

    Advances in Human Microbiome Science: Gut–Brain Interaction

    Organizers: John Hambor (Boehringer Ingelheim), Sarkis Mazmanian (California Institute of Technology), Nilufer Seth (Pfizer), Erick Young (Boehringer Ingelheim), Sonya Dougal (The New York Academy of Sciences), and Caitlin McOmish (The New York Academy of Sciences)

    There is growing interest in the connection between gut microbiota and the central nervous system. This eBriefing discusses gut–brain interactions and the possibility of targeting the microbiome with a focus on CNS health.

    May 17, 2016

    Emerging Approaches to Cancer Immunotherapy

    Organizers: Renier Brentjens (Memorial Sloan Kettering Cancer Center), George Zavoico (Jones Trading Institutional Services), Sonya Dougal (The New York Academy of Sciences), and Caitlin McOmish (The New York Academy of Sciences)

    Cancer immunotherapy, which engages the immune system to detect and destroy cancer cells, has gained popularity and success in recent years. This eBriefing features investigational approaches to better engineer or train the immune system to improve its responses, combat treatment resistance, and avoid adverse effects.

    May 13, 2016

    Editor's Guide to Writing and Publishing Your Paper

    Speaker: Brooke Grindlinger, Chief Scientific Officer, Scientific Programs & Blavatnik Awards (The New York Academy of Sciences)

    Publishing is critical to the scientific profession yet few opportunities exist for science PhDs to gain formal training in this area. A former editor for the Journal of Clinical Investigation provided an inside look into the editorial review process and how to present scientific results.

    April 26, 2016

    Regenerative Medicine: Transitioning Therapeutics from Cells to the Clinic

    Organizers: Jane S. Lebkowski (Asterias Biotherapeutics), George Zavoico (JonesTrading Institutional Services), Sonya Dougal (The New York Academy of Sciences), and Caitlin McOmish (The New York Academy of Sciences)

    The field of regenerative medicine is burgeoning with cell-based therapies designed to enhance or correct cell function. This eBriefing considers efforts to rethink clinical, regulatory, and manufacturing approaches to accelerate the transition of these therapies to the clinic.

    April 19, 2016

    Developing Scientists through Outreach

    Keynote Speakers: Emily Rice (College of Staten Island, CUNY), Mark Stewart (SUNY Downstate Medical Center), and Robert Tai (University of Virginia)

    Placing STEM students and postdocs in K–12 learning environments to mentor and teach is a well-known strategy to repair the leaky STEM pipeline. This eBriefing reviews STEM mentoring programs and other outreach strategies for scientists.

    March 16, 2016

    Microbes in the City: Mapping the Urban Genome

    Keynote Speakers: Jo Handelsman (White House Office of Science and Technology Policy), W. Ian Lipkin (Columbia University), Curtis Huttenhower (Harvard T.H. Chan School of Public Health), and Coby Schal (North Carolina State University)

    Metagenomics uses high-throughput DNA sequencing to study the huge populations of unculturable microbes in the urban environment. This eBriefing reviews work to map the urban metagenome to probe the microbial communities in the buildings and subways, soil and sewers in our cities.

    March 3, 2016

    Clinical and Nutrition Interventions to Manage Disease-related Loss of Lean Body Mass

    Organizers: David Evans (Ohio State University), Refaat Hegazi (Abbott Nutrition Health Institute), Gerard Mullin (Johns Hopkins Medicine), Dennis H. Sullivan (University of Arkansas for the Medical Sciences), Kathy West (Abbott Nutrition Health Institute), Amy R. Beaudreault (The Sackler Institute for Nutrition Science), and Julie Shlisky (The Sackler Institute for Nutrition Science)

    Hospitalized patients frequently experience loss of muscle mass and function, with negative outcomes for recovery, quality of life, and mortality. This eBriefing reviews interventions, including investigational strategies, for disease-related muscle mass loss.

    February 12, 2016

    Little Beans, Big Opportunities: Using Pulses to Meet Today's Global Health Challenges

    Keynote Speaker: Sonny Ramaswamy (USDA National Institute of Food and Agriculture)

    The United Nations declared 2016 the International Year of Pulses, highlighting the potential of dry peas, beans, lentils, and chickpeas to improve human health and agricultural sustainability. This eBriefing considers how pulse consumption contributes to health and how food systems could be improved to promote pulse production.

    February 2, 2016

    Alzheimer's Disease and Tau: Pathogenic Mechanisms and Therapeutic Approaches

    Organizers: Robert Martone (St. Jude Children's Research Hospital) and Sonya Dougal (The New York Academy of Sciences)

    Tau pathology is a hallmark of many devastating neurological disorders, including frontotemporal dementia, TBI, Down syndrome, focal cortical dysplasia, and Alzheimer's disease. This eBriefing explores tau-related mechanisms of neurodegeneration and emerging therapeutic strategies focused on tau.

    January 28, 2016

    Toward Evidence-based Nutrition Policy: Methods, Implementation, and Political Reality

    Keynote Speakers: Sonia Angell (NYC Department of Health and Mental Hygiene) and Rogan Kersh (Wake Forest University)

    Public policy for nutrition aims to assist people in making healthier food choices. This eBriefing looks at current evidence in nutrition policy making, including assessments of recent public policy interventions intended to improve nutrition and reduce obesity.

    January 25, 2016

    Pre-Approval Access: Can Compassion, Business, and Medicine Coexist?

    Organizers: Alison Bateman-House (NYU School of Medicine), Melanie Brickman Stynes (The New York Academy of Sciences), Arthur Caplan (NYU School of Medicine), Brooke Grindlinger (The New York Academy of Sciences), and Erick Tatro (The New York Academy of Sciences)

    This eBriefing explores pre-approval access to investigational medicines, the prospective benefits of which may outweigh the potential risks for critically ill patients. In a series of debates, representatives of governments, pharmaceutical companies, patient groups, NGOs, and foundations discussed ethical and safety challenges for pre-approval access and compassionate use programs.

    January 22, 2016

    Current Evidence on Noncaloric Sweeteners and their Health Implications

    Speakers: Gary D. Foster (Weight Watchers International Inc.), John Glendinning (Barnard College), and Rick Mattes (Purdue University)

    This eBriefing examines the current research on noncaloric sweeteners approved by the Food and Drug Administration for use in foods and beverages in the United States, particularly studies assessing how the compounds affect weight management and health.

    January 13, 2016

    Grantsmanship for Postdocs: Navigating the K99/R00 Award

    Speaker: Jaime S. Rubin (Columbia University)

    This eBriefing reviews grant writing for the NIH K99/R00 career transition award, which helps PhDs and physician-scientists move from postdoc to independent research.

    January 12, 2016

    Phenotypic and Biomarker-based Drug Discovery

    Organizers: Michael Foley (Tri-Institutional Therapeutics Discovery Institute), Ralph Garippa (Memorial Sloan-Kettering Cancer Center), David Mark (F. Hoffmann-La Roche), Lorenz Mayr (Astra Zeneca), John Moffat (Genentech), Marco Prunotto (F. Hoffmann-La Roche), and Sonya Dougal (The New York Academy of Sciences)

    This eBriefing considers the merits of phenotypic drug discovery, which is experiencing a renaissance of interest. The method aims to find therapeutically useful compounds by screening thousands of substances for functional cellular outputs.

    December 22, 2015

    Advances in Human Microbiome Science: Intestinal Diseases

    Organizers: Mercedes Beyna (Pfizer), John Hambor (Boehringer Ingelheim), Nilufer Seth (Pfizer), Erick Young (Boehringer Ingelheim), and Sonya Dougal (The New York Academy of Sciences)
    Keynote Speaker: Stanislav Dusko Ehrlich (French National Institute for Agricultural Research; King's College London)

    The human colon microbiota form one of the densest bacterial ecosystems, with 100 trillion microorganisms. This eBriefing focuses on the causal relationships between gut microbiota and intestinal health and disease.

    December 15, 2015

    Mobile Health: The Power of Wearables, Sensors, and Apps to Transform Clinical Trials

    Organizers: Glen de Vries (Medidata Solutions), John J. Mastrototaro (Medtronic), Bernard Munos (FasterCures), Fiorenzo Omenetto (Tufts University), Leonard Sacks (U.S. Food and Drug Administration), Melanie Brickman Stynes (The New York Academy of Sciences), Brooke Grindlinger (The New York Academy of Sciences), and Daniel Radiloff (The New York Academy of Sciences)

    Continuous health monitoring via wearable sensors, mobile devices, and apps is now possible. This eBriefing considers the use of real-time biometric data obtained from these technologies in medical care and clinical trials and looks at security and regulatory issues for health data.

    November 25, 2015

    From Tumor Suppressors to Oncogenic Dynamics: The 2015 Dr. Paul Janssen Award Symposium

    Featured Speaker: Bert Vogelstein (Johns Hopkins School of Medicine; Howard Hughes Medical Institute)

    This eBriefing features Bert Vogelstein, recipient of the 2015 Dr. Paul Janssen Award for Biomedical Research for his work characterizing the underlying mechanisms of cancer and for his discoveries' clinical applications. Topics at the forefront of precision medicine are also described.

    October 27, 2015

    The 2015 Blavatnik Science Symposium

    Keynote Speakers: Michal Lipson (Columbia University) and Carl Zimmer (The New York Times)

    The second annual Blavatnik Science Symposium showcased the work of the winners and finalists of the Blavatnik Awards for Young Scientists. The symposium also featured keynote lectures and panels on communicating science, artificial intelligence, career reinvention, and the future of computing.

    September 29, 2015

    Leveraging Big Data and Predictive Knowledge to Fight Disease

    Organizers: Walter Jessen (Covance Inc.), Robert Martone (St. Jude Children's Research Hospital), and Sonya Dougal (The New York Academy of Sciences)
    Keynote Speaker: Niven R. Narain (Berg Pharma)

    High-throughput measurements and powerful computing allow researchers to interrogate vast quantities of data; precision medicine relies on such data analyses to develop targeted therapeutics. This eBriefing explores how big data and predictive knowledge are used to guide drug development and clinical trials.

    September 10, 2015

    Harnessing Cell Signaling to Treat Cancer: The 2015 Ross Prize in Molecular Medicine

    Speakers: José Baselga (Memorial Sloan-Kettering Cancer Center) and Lewis C. Cantley (Weill Cornell Medical College)

    This eBriefing features Lewis C. Cantley, recipient of the 2015 Ross Prize in Molecular Medicine for his discoveries of signaling pathways in cancer cells. Recent work to advance precision medicine in cancer is also described.