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  • Academy eBriefings

  • eBriefing

    Click Chemistry in Biology and Medicine

    Organizers: Peng Wu (Albert Einstein College of Medicine) and Jennifer Henry (formerly at The New York Academy of Sciences)
    Keynote Speakers: Jim Paulson (Scripps Research Institute) and K. Barry Sharpless (Scripps Research Institute)

    This eBriefing explores recent developments in the search for click reactions with applications in disease diagnosis and therapy.

    In this eBriefing

    • Design of ligands to target chemotherapeutics and manipulate the immune system.
    • Design of reagents to study redox-dependent signaling and advanced glycation end products. ARMs as potential therapeutics.
    • A new class of compounds for developing click reactions.
  • Recent eBriefings 

    November 21, 2014

    Click Chemistry in Biology and Medicine

    Organizers: Peng Wu (Albert Einstein College of Medicine) and Jennifer Henry (formerly at The New York Academy of Sciences)
    Keynote Speakers: Jim Paulson (Scripps Research Institute) and K. Barry Sharpless (Scripps Research Institute)

    Click chemistry mimics the simplicity of reactions found in nature for synthesizing large complex molecules, proceeding via the stepwise addition of small building blocks with minimal toxic byproducts. This eBriefing explores recent developments in the search for click reactions with applications in disease diagnosis and therapy.

    November 12, 2014

    Elucidating GPCR Functional Selectivity for Drug Development

    Organizers: John A. Allen (Pfizer), Mercedes Beyna (Pfizer), Bryan L. Roth (University of North Carolina School of Medicine), and Jennifer Henry (formerly at The New York Academy of Sciences)

    This eBriefing looks at how to exploit biased ligand signaling at GPCRs to improve therapeutics for cardiovascular and CNS disorders. GPCRs signal via canonical pathways involving G proteins and via other signaling proteins, including β-arrestins. Discovering ligands with the desired signaling bias enables beneficial efficacy while reducing side effects.

    November 5, 2014

    From Bacterial Immunity to Genome Editing: The 2014 Dr. Paul Janssen Award Symposium

    Featured Speakers: Emmanuelle Charpentier (Helmholtz Centre for Infection Research, Hannover Medical School, Germany; Umeå University, Sweden) and Jennifer Doudna (University of California, Berkeley; Howard Hughes Medical Institute)

    This eBriefing features Emmanuelle Charpentier and Jennifer Doudna, recipients of the 2014 Dr. Paul Janssen Award for Biomedical Research for their role in understanding and adapting the CRISPR/Cas system for genome editing. Applications of the technique in human disease research and therapy are also described.

    October 14, 2014

    Fifty Years of the Genetic Code: Honoring the Legacy of Marshall Nirenberg

    Organizers: C. Thomas Caskey (Baylor College of Medicine), Brian Clark (University of Aarhus, Denmark), Gregory A. Petsko (Weill Cornell Medical College), and Jennifer Henry (formerly at The New York Academy of Sciences)

    The identification of the genetic code has offered many opportunities for further scientific discovery. This eBriefing documents a symposium that honored the legacy of Nobel laureate Marshall Nirenberg and showcased research in a range of therapeutic areas.

    September 5, 2014

    Demyelination and Remyelination: From Mechanism to Therapy

    Keynote Speaker: Robin Franklin (Wellcome Trust – MRC Cambridge Stem Cell Institute, University of Cambridge)

    This eBriefing highlights biological and clinical findings in remyelination and repair in genetic, inflammatory, infectious, cerebrovascular, and neurodegenerative conditions and injuries. It also features new techniques for imaging myelin changes in the brain and for screening molecular targets, as well as emerging therapeutics that promote remyelination.

    August 12, 2014

    Advances in Immunomodulation: The 2014 Ross Prize in Molecular Medicine

    Speakers: James P. Allison (University of Texas MD Anderson Cancer Center), Charles A. Dinarello (University of Colorado–Denver), and John J. O'Shea (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH)

    This eBriefing features John J. O'Shea, recipient of the 2014 Ross Prize in Molecular Medicine for his discoveries in immunology and cytokine biology. Recent research on therapies targeting cytokine signaling in autoimmune and inflammatory diseases and checkpoint modulators in cancer is also described.

    July 17, 2014

    The Biology of Aging: Novel Drug Targets for Neurodegenerative Disease

    Organizers: Howard Fillit (Alzheimer's Drug Discovery Foundation), Kevin J. Lee (Lawrence Ellison Foundation), and Jennifer Henry (The New York Academy of Sciences)

    Age is the major risk factor for Alzheimer's disease, and key pathways in aging biology offer targets for novel drugs. This eBriefing explores advances in the science of aging and in drug discovery for Alzheimer's and other neurodegenerative diseases.

    July 15, 2014

    HIV 2014: Science, Community, and Policy for Key Vulnerable Populations

    Organizers: Chris Beyrer (Johns Hopkins Bloomberg School of Public Health), Peter Godfrey-Faussett (UNAIDS), Ani Shakarishvili (UNAIDS), Yegor Voronin (Global HIV Vaccine Enterprise), and Jennifer Henry (The New York Academy of Sciences)

    The UNAIDS vision of zero new HIV infections, zero AIDS-related deaths, and zero discrimination calls for a global approach to HIV research and policy. This eBriefing focuses on improving outcomes for HIV in key vulnerable populations.

    July 3, 2014

    Malaria 2014: Advances in Pathophysiology, Biology, and Drug Development

    Organizers: Johanna P. Daily (Albert Einstein College of Medicine), David A. Fidock (Columbia University Medical Center), and Jennifer Henry (The New York Academy of Sciences)
    Keynote Speakers: Jane M. Carlton (New York University), Rick M. Fairhurst (National Institute of Allergy and Infectious Diseases, NIH), and Terrie E. Taylor (Michigan State University)

    Despite a 25% reduction in global malaria mortality since 2000, around half the world's population lives in areas where malaria is endemic. This eBriefing highlights a symposium held on World Malaria Day to examine breakthroughs in pathophysiology, drug development, and pre-erythrocytic and liver-stage biology.

    June 20, 2014

    Affective Disorders: Qatar Clinical Neuroscience Conference

    Chairs: Matthew E. Fink (Weill Cornell Medical College), Javaid I. Sheikh (Weill Cornell Medical College in Qatar), Melanie Brickman Stynes (The New York Academy of Sciences), and Brooke Grindlinger (The New York Academy of Sciences)

    This eBriefing highlights research on affective disorders, debilitating mood-related psychiatric illnesses such as depression and bipolar disorder that result from an intrinsic or chronic dysfunction of the brain, either within the cells or in their connectivity. Topics include animal models, translational medicine, advances in neuropsychiatry, and clinical approaches based on new understanding of disease heterogeneity.

    June 20, 2014

    Stroke and Traumatic Brain Injury: Qatar Clinical Neuroscience Conference

    Chairs: Matthew E. Fink (Weill Cornell Medical College), Javaid I. Sheikh (Weill Cornell Medical College in Qatar), Melanie Brickman Stynes (The New York Academy of Sciences), and Brooke Grindlinger (The New York Academy of Sciences)

    This eBriefing highlights research on brain disorders caused by external conditions such as cerebrovascular disease, stroke, and TBI, which result in the damage or death of healthy, functioning cells and brain tissue. Topics include pathophysiology, therapeutic insights, and clinical care to treat dysfunction and damage.

    June 6, 2014

    Consumer Behavior and Food Science Innovations for Optimal Nutrition

    Keynote Speaker: Joanne Guthrie (U.S. Department of Agriculture)

    This eBriefing looks at how research on consumer behavior can be applied to advance healthy and sustainable nutrition. It discusses consumer food choice, policy making, dietary diversity, food design and food form, product development, physiology and psychology, social influence, and technology.

    May 29, 2014

    An Introduction to Teaching Science Online

    Speakers: Vincent Racaniello (Columbia University Medical Center) and David Randle (American Museum of Natural History)

    This eBriefing provides an introduction to teaching science online, with an overview of online teaching platforms and strategies for designing courses and engaging, assessing, and retaining students.

    May 28, 2014

    Lung Cancer: Advances in Current Treatment Modalities and Patient Classification

    Organizers: Magdalena Alonso-Galicia (Forest Research Institute), Shashidhar S. Jatiani (Forest Research Institute), Huiping Jiang (Boehringer Ingelheim Pharmaceuticals), George Zavoico (HC Wainwright), and Jennifer Henry (The New York Academy of Sciences)
    Speakers: Rolf Brekken (UT Southwestern Medical Center), Jessica S. Donington (NYU Langone Medical Center), Balazs Halmos (Columbia University Medical Center), Roy S. Herbst (Yale School of Medicine), and Suresh S. Ramalingam (Emory University)

    Recent treatment advances in lung cancer supported by a better understanding of genetic heterogeneity may increase survival rates. This eBriefing features updates on common mutations and intraoperative chemotherapy, as well as insights from clinical trials.

    May 16, 2014

    Clinical and Economic Outcomes of Nutrition Interventions across the Continuum of Care

    Keynote Speaker: Kelly Tappenden (University of Illinois)

    This eBriefing focuses on the clinical and economic impacts of nutritional interventions across the continuum of care. It explores the role nutrition plays in clinical and home care settings, as well as new approaches to integrated care and the delivery of interventions.

    May 2, 2014

    Systems Biology Approaches to Secondary Metabolites and Metabonomics

    Organizers: Manuel X. Duval (Boehringer Ingelheim Pharmaceuticals; University of New Haven), Thomas B. Freeman (Boehringer Ingelheim Pharmaceuticals), and Jennifer Henry (The New York Academy of Sciences)
    Speakers: Sean F. Brady (The Rockefeller University), Steven Edgar (Massachusetts Institute of Technology), Justin Nodwell (University of Toronto, Canada), and Kang Zhou (Massachusetts Institute of Technology)

    Secondary metabolites, or idiolites, play many roles in biological systems, including communication, defense, and signaling. This eBriefing explores a systems biology approach to secondary metabolites and their networks, looking at their biological effects and potential benefits for human health.

    April 25, 2014

    How to Make Eggs in Space

    Moderator: Dave Mosher (Popular Science)
    Panelists: Charles Camarda (NASA) and Sara Zwart (NASA)

    The first event of the Academy's Mis/Adventures in Science series offered an insider's perspective on some of the less discussed challenges of life in space, such as what to eat for dinner and how to eat it in zero gravity.

    April 18, 2014

    Fast-tracking Alzheimer's Research: Global Alzheimer's Platform Design Workshop

    Team Leaders: Paul Aisen (University of California, San Diego), Russell L. Barton (Eli Lilly and Company), Randall J. Bateman (Washington University), Howard Feldman (University of British Columbia, Canada), Michael T. Ropacki (Janssen Research & Development), Andrew Satlin (Eisai Inc.), Eric R. Siemers (Eli Lilly and Company), Reisa A. Sperling (Harvard Medical School), and Luc Truyen (Johnson & Johnson)

    The Global Alzheimer's Platform (GAP) aims to establish a drug discovery process to expedite AD research. This eBriefing documents a workshop convened to plan how to build the platform.

    April 11, 2014

    Nanomedicines: Addressing the Scientific and Regulatory Gap

    Organizers: Raj Bawa (Bawa Biotech LLC; Rensselaer Polytechnic Institute), Scott E. McNeil (Nanotechnology Characterization Laboratory – Frederick National Laboratory for Cancer Research), Stefan Mühlebach (Vifor Pharma Ltd.; University of Basel, Switzerland), Melanie Brickman Stynes (The New York Academy of Sciences), and Melinda Miller (The New York Academy of Sciences)
    Keynote Speaker: Sally Tinkle (Science and Technology Policy Institute, IDA)

    This eBriefing explores regulatory challenges in the nascent field of nanomedicines, focusing on the relevance and adequacy of existing frameworks, the availability and expertise of regulators, and safety concerns.

    March 19, 2014

    Perspectives in STEM: An Evening with Laurie Leshin

    Speaker: Laurie Leshin (Rensselaer Polytechnic Institute)

    Laurie Leshin, Dean of the School of Science at Rensselaer Polytechnic Institute and former NASA executive, related her career in science and technology, discussed career development and the future of STEM, and provided updates from the Mars Curiosity rover mission.