Overview

At the June 2, 2009, meeting of the Systems Biology Discussion Group, four prominent biologists showed how the systems approach can be used to study cancer. As their results showed, the strategy can reveal both interesting biology and promising new therapeutic targets for one of the world's deadliest diseases.

Andrea Califano presented evidence that computer algorithms can accurately predict the signaling networks underlying tumor development. Galit Lahav showed that DNA damage causes p53 activity to oscillate until the damage is repaired. Chris Sander presented work suggesting that genetically diverse tumors may share common signaling patterns. Arnold Levine discussed work showing that single base changes in p53 and related signaling molecules can affect both cancer rates and fertility.

Use the tabs above to find a meeting report and multimedia from this event.