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  • Clinical Medicine

  • Events 

    Monday, November 3, 2014 | 8:00 AM - 4:30 PM

    Gene Network Changes in Alzheimer's Disease: Potential Points for Therapeutic Intervention

    Speakers: Kwame O. Affram (Uniformed Services University), Erik H.W.G.M. Boddeke (University Medical Center Groningen), Oleg Butovsky (Brigham and Women's Hospital and Harvard Medical School), Philip L. De Jager (Harvard University and Brigham and Women's Hospital), Joseph El Khoury (Massachusetts General Hospital and Harvard Medical School), Miriam Merad (Icahn School of Medicine at Mount Sinai), Michael C. Oldham (University of California, San Francisco), Vishal Sahni (Eisai Inc), Bin Zhang (Icahn School of Medicine at Mount Sinai)

    Next generation sequencing of Alzheimer’s disease (AD) progression reveals gene networks within microglial pathways. This symposium focuses on microglia biology, molecular signatures specific to microglial phenotypes, and phenotype modulation.

    November 11 - 13, 2014

    Shaping the Developing Brain: Prenatal through Early Childhood
    Fifth Annual Aspen Brain Forum

    Keynote Speaker:Thomas R. Insel (National Institute of Mental Health)
    Speakers: Tracy L. Bale (University of Pennsylvania), Jay Belsky (University of California, Davis), Maureen Black (University of Maryland), Pia Britto (UNICEF), Serena Counsell (King's College London), Martha Farah (University of Pennsylvania), Edward Frongillo (University of South Carolina), Michael Georgieff (University of Minnesota), Takao Hensch (Harvard University), Sharon Lynn Kagan (Columbia University), Patricia Kuhl (Washington University), Ed Lein (Allen Institute for Brain Science), Betsy Lozoff (University of Michigan), Linda Mayes (Yale School of Medicine), Andrew N. Meltzoff (Washington University), Charles A. Nelson (Harvard University and Boston Children's Hospital), Joseph Piven (UNC School of Medicine, CIDD), Dana Suskind (University of Chicago), Nim Tottenham (UCLA)

    Discover the latest cognitive neuroscience research on infant and early childhood development; social, family, and nutritional factors that cause lasting changes to the brain; and intervention, education, and policy to help at-risk children.

    Tuesday, December 9, 2014 | 8:00 AM - 5:00 PM

    Diabetic Kidney Disease: Drug Discovery and Clinical Development Challenges

    Speakers: Matthew D. Breyer (Eli Lilly, Indianapolis, IN), Frank C. Brosius (University of Michigan Medical School, Ann Arbor, MI), Benjamin D. Humphreys (Harvard Institutes of Medicine, Boston, MA), Matthias Meier (F. Hoffmann-LaRoche Ltd, Basel, Switzerland), Shahnaz Shahinfar (S. Shahinfar Consulting, Inc. and The Children's Hospital of Philadelphia), Katalin Susztak (University of Pennsylvania, Philadelphia, PA), Aliza Thompson (US Food & Drug Administration, Silver Spring)

    Identifying and prosecuting drug targets is challenging due to a poor understanding of pathogenesis and few biomarkers. This symposium identifies targets for preventive or therapeutic interventions and discusses challenges in clinical development.

    Tuesday, January 27, 2015 | 8:30 AM - 4:30 PM

    Growing Pains: The Future of Cytokines as Immunotherapies for Oncology, Infection and Inflammatory Disease

    Keynote Speaker: James W. Mier (Beth Israel Deaconess Medical Center/ Harvard Medical School)
    Speakers: Stephen D. Gillies (Provenance Biopharmaceuticals, Carlisle MA), Dario Neri (Philogen, Zurich, Switzerland), Gilles Uzé (Université Montpellier II, Montpellier, France), K. Dane Wittrup (Massachusetts Institute of Technology)

    Systemic toxicity currently prevents exploiting the potential of many cytokines to treat cancer, viral infections, inflammatory and autoimmune conditions. Targeted delivery of immune-stimulatory or immune-regulatory cytokines offers much promise.

    Tuesday, February 24, 2015 | 8:30 AM - 4:30 PM

    Harnessing the Potential of Genome Editing for Drug Discovery: Translational Frontiers of in vitro and in vivo Applications

    Speakers: James Inglese (National Center for Advancing Translational Sciences), Yi Yang (Novartis Institutes for Biomedical Research)

    The emergence of genome editing technologies such as TALEN and CRISPR/Cas9 are revolutionizing our ability to rapidly engineer mammalian systems. This symposium explores the frontiers of genome editing and potential to aid therapeutic development.

  • Past Events

    Tuesday, October 28, 2014 | 8:30 AM - 5:00 PM

    Pharmacologic Resolution of Inflammation as a Novel Therapeutic Approach

    Speaker: Michael S. Conte (University of California-San Francisco), Milan Fiala (David Geffen School of Medicine at UCLA), Gabrielle Fredman (Columbia University), Bruce Levy (Harvard University, Brigham and Women's Hospital), Dipak Panigrahy (Beth Israel Deaconess Medical Center, Harvard Medical School), Mauro Perretti (Queen Mary University of London), Charles N. Serhan (Brigham & Women's Hospital, Harvard Medical School), Patricia J. Sime (University of Rochester School of Medicine), Rudolph E. Tanzi (Massachusetts General Hospital)

    Uncontrolled, chronic inflammation plays a key role in the progression of many diseases, and elucidation of biochemical pathways provides novel targets. This symposium reviews discoveries, approaches and opportunities for treatment and prevention.

    Friday, October 10, 2014 | 8:00 AM - 3:15 PM

    New Frontiers in the Neurobiology of Mental Illness

    Sold Out
    Keynote Speaker: The Honorable Patrick J. Kennedy
    Former United States Representative, Rhode Island; One Mind for Research; Kennedy Forum

    This conference will explore the translation of recent breakthroughs in neuroscience into therapies for the more than twenty-five percent of Americans suffering from mental illnesses such as schizophrenia, depression, fear and anxiety disorders, autism, and other psychiatric disorders. A keynote lecture by The Honorable Patrick J Kennedy will address strategies to simultaneously abolish the stigma surrounding mental illness in order to fully realize the potential of these new treatments to improve mental health.

    Thursday, October 9, 2014 | 8:00 AM - 4:00 PM

    Targeting Key Vulnerabilities in Pancreatic Cancer

    Keynote Speakers: Neesha Dhani (Princess Margaret Hospital, Toronto), Steven D. Leach (Memorial Sloan Kettering Cancer Center)
    Speakers: Gregory Beatty (University of Pennsylvania Perelman School of Medicine), Neesha C. Dhani (Division of Medical Oncology & Hematology, University Health Network, Princess Margaret Cancer Centre/Ontario Cancer Institute), Mikala Egeblad (Cold Spring Harbor Laboratory), Douglas T. Fearon (Weill Cornell Medical College and Cold Spring Harbor Laboratory), Elda Grabocka (Department of Biochemistry and Molecular Pharmacology, NYU Langone School of Medicine), Costas A. Lyssiotis (Weill Cornell Medical College ), George Miller (NYU Langone Medical Center), Michael Ports (Gilead Sciences), Curtis B. Thompson (Halozyme Therapeutics, Inc)

    Pancreatic cancer patients currently have limited therapeutic options. This symposium explores breakthroughs in the pathogenesis and progression of pancreatic cancer, and efforts to exploit key vulnerabilities for novel therapeutic interventions.

    Tuesday, September 30, 2014 | 8:30 AM - 5:00 PM

    Elucidating GPCR Functional Selectivity: Novel Opportunities for Drug Development

    Keynote Speaker: Nobel Laureate Robert J. Lefkowitz (Duke University Medical Center)
    Speakers: John A. Allen (Pfizer), Laura Bohn (The Scripps Research Institute - Florida), Marc G. Caron (Duke University Medical Center), Jonathan A. Javitch (Columbia University and New York State Psychiatric Institute), Terry Kenakin (University of North Carolina School of Medicine), Bryan L. Roth (University of North Carolina School of Medicine), JoAnn Trejo (University of California, San Diego), Jonathan D. Violin (Trevena Inc.)

    Hear academic, industry, basic and translational researchers, including Nobel Laureate Robert Lefkowitz (Duke University Medical Center) and discuss the development of functionally selective GPCR-biased ligands for CV and CNS disease drug discovery.

  • Publications 

    Annals

    Addiction Reviews

    Edited by George R. Uhl (National Institutes of Health, Baltimore, Maryland)

    The sixth installment of this annual series explores molecular and translational/therapeutic aspects of addiction.

    Volume 1327

    eBriefing

    Fifty Years of the Genetic Code: Honoring the Legacy of Marshall Nirenberg

    Organizers: C. Thomas Caskey (Baylor College of Medicine), Brian Clark (University of Aarhus, Denmark), Gregory A. Petsko (Weill Cornell Medical College), and Jennifer Henry (formerly at The New York Academy of Sciences)

    The identification of the genetic code has offered many opportunities for further scientific discovery. This eBriefing honors the legacy of Nobel laureate Marshall Nirenberg, who described the basic unit of the genetic code 50 years ago.

    Annals

    The 12th OESO World Conference: Cancers of the Esophagus

    Edited by Robert Giuli (Deputy Director of OESO, Executive Director of the OESO Foundation, Paris, France) and Asad Umar (National Cancer Institute, Rockville, Maryland)

    This Annals volume presents a compilation of expert views on topics related to esophageal cancers presented at the World Organization for Specialized Studies on Diseases of the Esophagus 12th World Conference.

    Volume 1325

    eBriefing

    Demyelination and Remyelination: From Mechanism to Therapy

    Keynote Speaker: Robin Franklin (Wellcome Trust – MRC Cambridge Stem Cell Institute, University of Cambridge)

    This eBriefing highlights biological and clinical findings in remyelination. It also features new techniques for imaging myelin and screening molecular targets, as well as therapeutics that promote remyelination.

  • Podcasts

    Podcast
    July 30, 2010

    Oxidative Stress

    Foods high in antioxidants are believed to fight oxidative stress. But what is oxidative stress? Two scientists from a recent NYAS conference break it down and discuss whether antioxidants have superpowers.

    Download (12 MB, 00:18:37)
    Podcast
    April 2, 2010

    More than a Yogurt Cup

    Delve into the world of prebiotic and probiotic science. We talk to three people in the field and learn why keeping the good microbes in our bodies happy means a lot for health.

    Download (14 MB, 00:21:21)
    Podcast
    January 29, 2010

    ADHD and the Brain

    Neuropsychologist Jeffrey Halperin is using behavioral therapy on preschoolers with attention deficit hyperactivity disorder (ADHD). He hopes to train their brains to develop in new ways and if effective, his therapies could offer permanent, drug-free treatment for the disorder.

    Download (11 MB, 00:17:30)
    Podcast
    January 15, 2010

    Feeling the Light

    Researchers at Harvard have discovered why the headaches of some migraine sufferers worsen when the person is exposed to light. Rami Burstein, the study's senior author, explains what's happening in the brain, and how they made the breakthrough.

    Download (15 MB, 00:22:48)
  • Translational Medicine Initiative

    Macy FoundationThe Translational Medicine Initiative represents a three-year partnership between the New York Academy of Sciences and the Josiah Macy, Jr. Foundation to support the translation of basic science research into clinical applications.

    Learn more at www.nyas.org/TransMed.