Monday, February 22, 2016 | 9:00 AM - 5:00 PM
Speakers: John F. DiPersio (Washington University School of Medicine), Jonathan D. Glass (Emory University School of Medicine), Edward O. Lanphier (Sangamo BioSciences, Inc.), Jane S. Lebkowski (Asterias Biotherapeutics), Racheli Ofir (Pluristem LTD), Mahendra Rao (Wake Forest University School of Medicine), Thomas Schulz (ViaCyte, Inc.), John D. Sinden (ReNeuron Limited), Katherine Tsokas (Janssen Research & Development)
Advances in gene editing have driven an explosion of pre-clinical cell-based therapies. This event addresses the need to rethink clinical, regulatory, & manufacturing approaches to accelerate the transition of drugs through the clinic.
Friday, March 4, 2016 | 9:00 AM - 6:00 PM
Early registration is strongly encouraged as the 2015 Symposium sold out well in advance.
Keynote Speakers: Sébastien Bubeck (Microsoft Research), Alex Graves (Google Research), Alexander Rakhlin (University of Pennsylvania), Ambuj Tewari (University of Michigan)
This symposium features keynote speakers in applied and theoretical machine learning as well as "spotlight" talks selected from poster abstract submissions.
March 30 - April 1, 2016
Keynote Speakers: Richard Gilbertson (Cambridge Cancer Center, University of Cambridge), Craig B. Thompson (Memorial Sloan Kettering Cancer Center)
Speakers: Scott Armstrong (Memorial Sloan Kettering Cancer Center), Eric Bouffet (The Hospital for Sick Children, Toronto), Stefan Burdach (Technical University of Munich, Germany), Michael Dyer (St. Jude Children's Research Hospital, Howard Hughes Medical Institute), Nancy Goodman (Kids V Cancer), Lee J. Helman (National Cancer Institute, National Institutes of Health), Nada Jabado (McGill University), Katherine A. Janeway (Dana-Farber Cancer Center, Harvard Medical School), Michael Jensen (Seattle Children's Hospital), Javed Khan (National Cancer Institute, National Institutes of Health), Andrew Kung (Columbia University Medical Center), A. Thomas Look (Dana-Farber Cancer Center, Harvard University), David C. Lyden (Weill Cornell Medical College), Elizabeth Maher (University of Texas Southwestern Medical Center), David Malkin (The Hospital for Sick Children), John Maris (The Children's Hospital of Philadelphia and the University of Pennsylvania), Yael Mossé (The Children’s Hospital of Philadelphia), Kathy Pritchard-Jones (Great Ormond Street Hospital for Children NHS Foundation Trust and University College London), Charles W.M. Roberts (St. Jude Children's Research Hospital), Michel Sadelain (Memorial Sloan Kettering Cancer Center), Paul M. Sondel (University of Wisconsin School of Medicine and Public Health), Poul H. Sorensen (University of British Columbia), Kimberly Stegmaier (Dana-Farber Cancer Institute), Michael D. Taylor (The Hospital for Sick Children, University of Toronto), Matthew Vander Heiden (The Koch Institute, Massachusetts Institute of Technology), Robert Wechsler-Reya (Sanford Burnham Prebys Institute of Medical Discovery)
Discover the latest on pediatric cancers from leading experts, including etiological differences between pediatric and adult cancers, epigenetics, mechanisms of metastasis and disease recurrence, risk factors, diagnostics, and novel treatment approaches.
April 13 - 14, 2016
Speakers: Domenico Accili (Columbia University), Timothy Ahles (Memorial Sloan Kettering Cancer Center), Kathryn Anastos (Albert Einstein College of Medicine), Nir Barzilai (Albert Einstein College of Medicine), James Becker (University of Pittsburgh), Caroline Blaum (New York University), Judith Campisi (Buck Institute for Research on Aging), Harvey J. Cohen (Duke University), Steven Deeks (AIDS Research Institute; University of California, San Francisco), Wendy Demark-Wahnefried (University of Alabama at Birmingham), Elissa Epel (University of California, San Francisco), Kristine Erlandson (University of Colorado), Claudia Gravekamp (Albert Einstein College of Medicine), Jeffrey Halter (University of Michigan), Kevin High (Wake Forest University), Peter Hunt (University of California, San Francisco), Arti Hurria (City of Hope National Medical Center), Beth Jamieson (University of California, Los Angeles), C. Ronald Kahn (Joslin Diabetes Center), Balakuntalam Kasinath (Barshop Institute for Longevity and Aging Studies; University of Texas Health Science Center), Gretchen Neigh (Emory University), Rosario Scalia (Temple University), Jan van Deursen (Mayo Clinic)
Explore how chronic diseases — specifically HIV/AIDS, diabetes, and cancer — can affect the seven mechanistic pillars of aging.
Thursday, April 28, 2016 | 9:00 AM - 4:30 PM
Keynote Speaker: Craig B Thompson (Memorial Sloan Kettering Cancer Center)
Speakers: Eric Campeau (Zenith Epigenetics), Ewelina Kulikowski (Resverlogix Corp), Keiko Ozato (National Institute of Child Health and Human Development), Roberto Pili (Indiana University School of Medicine), Patrick Trojer (Constellation), Christopher Vakoc (Cold Spring Harbor Laboratory)
Epigenetic abnormalities are a recognized contributing factor in tumorigenesis and other diseases. This symposium describes recent progress in validating the therapeutic potential of small molecule inhibitors targeting epigenetics marks.
Tuesday, December 8, 2015 | 8:30 AM - 4:45 PM
Speakers: David D'Alessio (Duke University), Richard DiMarchi (Indiana University), Jean-Philippe Fortin (Pfizer Global), Keld Fosgerau (Zealand Pharma A/S), Matthew R. Hayes (Perelman School of Medicine, University of Pennsylvania), George G. Holz (State University of New York), Beat Jucker (GlaxoSmithKline), Dong Seok Kim (National Institute on Aging / Peptron Inc), Lotte Bjerre Knudsen (Novo Nordisk), Patrick M. Sexton (Monash University), Konrad Talbot (Cedars-Sinai Medical Center)
GLP-1 receptor agonists have improved treatment options in type 2 diabetes, although realizing their promise in other areas remains challenging. This symposium highlights preclinical and clinical breakthroughs and opportunities for drug development.
Tuesday, October 27, 2015 | 8:00 AM - 5:00 PM
Speakers: Andras J. Bauer (Boehringer Ingelheim USA), Myles Fennell (Memorial Sloan-Kettering Cancer Center), Michael R. Jackson (Sanford Burnham Prebys Medical Discovery Institute), Jonathan A. Lee (Eli Lilly), Martin Main (AstraZeneca), Friedrich Metzger (F. Hoffmann-La Roche Ltd), Bruce A. Posner (University of Texas, Southwestern Medical Center), Yao Shen (Columbia University), Aravind Subramanian (Broad Institute), Giulio Superti-Furga (Austrian Academy of Sciences), Susanne Swalley (Novartis Institutes for Biomedical Research), Jitao David Zhang (F. Hoffmann-La Roche Ltd.)
This symposium aims to deepen our understanding of phenotypic drug discovery and to foster the exchange of ideas between industry-based and academic research scientists.
October 18 - 22, 2015
Keynote Speakers: Maria Domenica Cappellini (University of Milan) and Stuart H. Orkin (Boston Children's Hospital and Dana-Farber Cancer Institute)
Speakers: Emanuele Angelucci (Cancer Hospital "Armando Businco," Cagliari), Jodie L. Babitt (Massachusetts General Hospital), Jonathan M. Barasch (Columbia University), Daniel E. Bauer (Boston Children's Hospital; Dana-Farber Cancer Institute; Harvard Medical School), Sunil Bhandari (Hull and East Yorkshire Hospitals NHS Trust and Hull York Medical School), Caterina Borgna-Pignatti (University of Ferrara), Farid Boulad (Memorial Sloan-Kettering Cancer Center), Marina Cavazzana-Calvo (Hospital Necker, University Paris Descartes), David H.K. Chui (Boston University School of Medicine), Thomas D. Coates (Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine), Ann Dean (National Institutes of Health), David Dinan (Nemours Children’s Hospital), Alexander (Hal) Drakesmith (Radcliffe Department of Medicine, University of Oxford), Kathleen Durst (Cooley's Anemia Foundation), Giuliana Ferrari (San Raffaele-Telethon Institute for Gene Therapy), Steven Flamm (Northwestern Medical Center), Mark D. Fleming (Boston Children's Hospital), Ellen B. Fung (UCSF Benioff Children's Hospital Oakland), Andrea Giusti (Galliera Hospital), Olivier Hermine (Hospital Necker, University Paris Descartes), Doug Higgs (University of Oxford), Eldad Arie Hod (Columbia University), Janet L. Kwiatkowski (The Children's Hospital of Philadelphia; Perelman School of Medicine, University of Pennsylvania), Ashutosh (Ash) Lal (University of California San Francisco Benioff Children’s Hospital Oakland), Roberto Machado (University of Illinois College of Medicine), Takahiro Maeda (Brigham and Women's Hospital), Punam Malik (Cincinnati Children’s Hospital), Jeffery L. Miller (National Institute of Diabetes and Digestive and Kidney Diseases), David G. Nathan (Dana-Farber Cancer Institute), Elizabeth (Ella) Nemeth (University of California, Los Angeles), Ellis Neufeld (Boston Children's Hospital), Arthur Nienhuis (St. Jude Children's Research Hospital), Dudley Pennell (Imperial College London), Antonio Piga (Torino University), John Porter (University College London Hospitals), Scott Reeder (University of Wisconsin School of Medicine and Public Health), Stefano Rivella (Children's Hospital of Philadelphia), Thomas M. Ryan (The University of Alabama at Birmingham), Vijay Sankaran (Boston Children's Hospital and Dana-Farber Cancer Institute), Shalini Shenoy (St. Louis Children's Hospital), Ali Taher (American University of Beirut Medical Center), Swee Lay Thein, John F. Tisdale (National Heart, Lung, and Blood Institute), Suzy V. Torti (University of Connecticut Health Center), Tim M. Townes (The University of Alabama at Birmingham), Marsha J. Treadwell (Children's Hospital Oakland), Vip Viprakasit (Siriraj Hospital, Mahidol University), John C. Wood (Children's Hospital Los Angeles)
Global experts explore the biology of globin gene regulation and fetal hemoglobin induction; stem cell transplant, gene therapy strategies, and gene editing; and clinical issues in thalassemia treatment and imaging.
Thursday, October 15, 2015 | 8:00 AM - 5:00 PM
Speakers: Jonathan Braun (University of CaliforniaLos Angeles), Rodolphe Clerval (Enterome), Stanislav Dusko Ehrlich (King's College London), Michael A. Fischbach (University of California, San Francisco), Andy Goodman (Yale School of Medicine), Matthew R. Hepworth (Weill Cornell Medical College), Mingzhi Lin (New York University), Randy Longman (Weill Cornell Medical College), Sarkis Mazmanian (California Institute of Technology), Paul O'Toole (University College Cork), Noah W. Palm (Yale University School of Medicine), Tamar Ringel-Kulka (The University of North Carolina at Chapel Hill), R. Balfour Sartor (University of North Carolina School of Medicine)
In the human colon, the microbiome forms one of the densest bacterial ecosystems known in nature. This symposium will highlight recent research innovations and therapeutic applications from the microbiome with a focus on gut health.
Organizers: Robert Martone (St. Jude Children's Research Hospital) and Sonya Dougal (The New York Academy of Sciences)
This eBriefing explores tau-related mechanisms of neurodegeneration and emerging therapeutic strategies focused on tau.
Organizers: Michael Foley (Tri-Institutional Therapeutics Discovery Institute), Ralph Garippa (Memorial Sloan-Kettering Cancer Center), David Mark (F. Hoffmann-La Roche), Lorenz Mayr (Astra Zeneca), John Moffat (Genentech), Marco Prunotto (F. Hoffmann-La Roche), and Sonya Dougal (The New York Academy of Sciences)
This eBriefing considers the merits of phenotypic drug discovery, which is experiencing a renaissance of interest. The method aims to find therapeutically useful compounds by screening thousands of substances for functional cellular outputs.
Organizers: Mercedes Beyna (Pfizer), John Hambor (Boehringer Ingelheim), Nilufer Seth (Pfizer), Erick Young (Boehringer Ingelheim), and Sonya Dougal (The New York Academy of Sciences)
Keynote Speaker: Stanislav Dusko Ehrlich (French National Institute for Agricultural Research; King's College London)
This eBriefing focuses on the causal relationships between gut microbiota and intestinal health and disease.
Edited by Thomas L. Rothstein
(The Feinstein Institute for Medical Research), Leonore A. Herzenberg
(Stanford University School of Medicine), Nichol E. Holodick
(The Feinstein Institute for Medical Research), and Eliver Ghosn
(Stanford University School of Medicine)
These papers discuss the physiological role of a unique subpopulation of B lymphocytes called B-1 cells.