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  • Drug Development

  • Events 

    Monday, September 15, 2014 | 12:00 PM - 4:00 PM

    Click Chemistry in Biology and Medicine: New Developments and Strategies

    Keynote Speakers: Jim Paulson (The Scripps Research Institute), K. Barry Sharpless (The Scripps Research Institute)
    Speakers: Yimon Aye (Cornell University), David A. Spiegel (Yale University), Peng Wu (Albert Einstein College of Medicine)

    Click chemistry offers a reliable method for discovering chemical connectivity, with great potential in drug discovery and biomedical research. This symposium explores recent developments that offer new technologies for disease diagnosis and therapy.

    Tuesday, September 30, 2014 | 8:30 AM - 5:00 PM

    Elucidating GPCR Functional Selectivity: Novel Opportunities for Drug Development

    Keynote Speaker: Nobel Laureate Robert J. Lefkowitz (Duke University Medical Center)
    Speakers: Bryan Roth (University of North Carolina at Chapel Hill School of Medicine), Terry Kenakin (University of North Carolina at Chapel Hill School of Medicine), Marc G. Caron (Duke University Medical Center), Laura Bohn (The Scripps Research Institute), Michael Ehlers (Pfizer), JoAnn Trejo (University of California-San Diego), Jonathan Violin (Trevena, Inc.)

    Hear academic, industry, basic and translational researchers, including Nobel Laureate Robert Lefkowitz (Duke University Medical Center) and discuss the development of functionally selective GPCR-biased ligands for CV and CNS disease drug discovery.

    Tuesday, October 28, 2014 | 8:30 AM - 5:00 PM

    Pharmacologic Resolution of Inflammation as a Novel Therapeutic Approach

    Speaker: Michael S. Conte (University of California-San Francisco, San Francisco, CA), Milan Fiala (David Geffen School of Medicine at UCLA, Los Angeles, CA), Gabrielle Fredman (Columbia University, New York, NY), Bruce Levy (Harvard University, Brigham and Women's Hospital, Boston, MA), Dipak Panigrahy (Beth Israel Deaconess Medical Center, Boston, MA), Mauro Perretti (William Harvey Research Institute, London, UK), Charles N. Serhan (Harvard University, New York, NY), Patricia J. Sime (University of Rochester School of Medicine, Rochester, NY), Rudy Tanzi (Massachusetts General Hospital, Charlestown, MA)

    Uncontrolled, chronic inflammation plays a key role in the progression of many diseases, and elucidation of biochemical pathways provides novel targets. This symposium reviews discoveries, approaches and opportunities for treatment and prevention.

    Saturday, November 15, 2014 | 11:00 AM - 4:00 PM

    Risky Business – A Pharmaceutical Industry Strategy Workshop

    Moderators: Florian Jehle (Catenion), Jan-Philipp Kruse (Catenion)

    This course gives professionals from inside and outside the pharmaceutical industry—including students and postdocs—a much better understanding of how the R&D and business development and licensing processes operate.

    Tuesday, December 9, 2014 | 8:00 AM - 5:00 PM

    Diabetic Kidney Disease: Drug Discovery and Clinical Development Challenges

    Speakers: Matthew D. Breyer (Eli Lilly, Indianapolis, IN), Frank C. Brosius (University of Michigan Medical School, Ann Arbor, MI), Benjamin D. Humphreys (Harvard Institutes of Medicine, Boston, MA), Matthias Meier (F. Hoffmann-LaRoche Ltd, Basel, Switzerland), Shahnaz Shahinfar (The Children's Hospital of Philadelphia, Philadelphia, PA), Katalin Susztak (University of Pennsylvania, Philadelphia, PA), Aliza Thompson (US Food & Drug Administration, Silver Spring)

    Identifying and prosecuting drug targets is challenging due to a poor understanding of pathogenesis and few biomarkers. This symposium identifies targets for preventive or therapeutic interventions and discusses challenges in clinical development.

  • Past Events

    Thursday, June 26, 2014 | 7:45 AM - 6:00 PM

    Demyelination and Remyelination: From Mechanism to Therapy

    Keynote Speaker: Robin Franklin (Wellcome Trust – MRC Cambridge Stem Cell Institute, University of Cambridge)

    This translational conference will highlight biological and clinical findings in myelin development, new techniques for brain imaging and for screening molecular targets, and novel therapeutics that promote remyelination.

    Tuesday, May 20, 2014 | 8:30 AM - 5:00 PM

    Hot Technologies for Developing Next-Gen Biologics

    Speakers: Timothy Charlebois (Pfizer), David King (AnaptysBio Inc.), William M. Pardridge (Brain Research Institute, UCLA), Steven J. Projan (MedImmune), Sachdev Siddhu (University of Toronto), E. Sally Ward (UT Southwestern), Patrick C. Wilson (The University of Chicago), K. Dane Wittrup (Massachusetts Institute of Technology)

    New technologies are pivotal in developing next-generation biologics. This symposium highlights novel technologies in the discovery of new biologics, elucidating in vivo mechanisms of therapeutic proteins, and manufacturing and delivery processes.

    Friday, May 9, 2014 | 8:00 AM - 4:00 PM

    The Biology of Aging: Novel Drug Targets for Neurodegenerative Disease

    Speakers: Carmela R. Abraham (Boston University School of Medicine), Eric H. Baehrecke (University of Massachusetts Medical School), Nir Barzilai (Albert Einstein College of Medicine), Jerry R. Colca (Metabolic Solutions Development Company), Brendan D. Manning (Harvard School of Public Health), Beth Stevens (Harvard Medical School), D. Martin Watterson (Northwestern University Feinberg School of Medicine), Haung Yu (Columbia University), Jeffrey W. Kelly (The Scripps Research Institute), Richard I. Morimoto (Northwestern University)

    Age is the major risk factor for Alzheimer's disease, and key pathways in aging biology offer targets for novel drugs. Explore recent advances in the science of aging and innovative drug discovery for Alzheimer's and other neurodegenerative diseases.

    Friday, April 25, 2014 | 8:00 AM - 5:30 PM

    Malaria 2014: Advances in Pathophysiology, Biology and Drug Development

    Keynote Speakers: Jane M. Carlton (New York University), Rick M. Fairhurst (National Institute of Allergy and Infectious Disease, NIH), Terrie E. Taylor (Michigan State University)
    Speakers: Myles Akabas (Albert Einstein College of Medicine), Purnima Bhanot (UMDNJ - New Jersey Medical School), Liwang Cui (Pennsylvania State University), Mahalia S. Desruisseaux (Albert Einstein College of Medicine), Miriam K. Laufer (University of Maryland School of Medicine), Laura Kirkman (Weill Cornell Medical College), Marcus Lee (Columbia University), Alexander Ploss (Princeton University), Photini Sinnis (Johns Hopkins University)

    Despite a 25% reduction in global malaria mortality since 2000, around half the world's population is at risk. Join us on World Malaria Day to examine breakthroughs in pathophysiology, pre-erythrocytic and liver stage biology, and drug development.

  • Publications 

    eBriefing

    The Biology of Aging: Novel Drug Targets for Neurodegenerative Disease

    Organizers: Howard Fillit (Alzheimer's Drug Discovery Foundation), Kevin J. Lee (Lawrence Ellison Foundation), and Jennifer Henry (The New York Academy of Sciences)

    This eBriefing explores advances in the science of aging and in drug discovery for Alzheimer's and other neurodegenerative diseases.

    eBriefing

    Malaria 2014: Advances in Pathophysiology, Biology, and Drug Development

    Organizers: Johanna P. Daily (Albert Einstein College of Medicine), David A. Fidock (Columbia University Medical Center), and Jennifer Henry (The New York Academy of Sciences)
    Keynote Speakers: Jane M. Carlton (New York University), Rick M. Fairhurst (National Institute of Allergy and Infectious Diseases, NIH), and Terrie E. Taylor (Michigan State University)

    This eBriefing highlights a symposium held on World Malaria Day to examine breakthroughs in pathophysiology, drug development, and pre-erythrocytic and liver-stage biology.

    eBriefing

    Lung Cancer: Advances in Current Treatment Modalities and Patient Classification

    Organizers: Magdalena Alonso-Galicia (Forest Research Institute), Shashidhar S. Jatiani (Forest Research Institute), Huiping Jiang (Boehringer Ingelheim Pharmaceuticals), George Zavoico (HC Wainwright), and Jennifer Henry (The New York Academy of Sciences)
    Speakers: Rolf Brekken (UT Southwestern Medical Center), Jessica S. Donington (NYU Langone Medical Center), Balazs Halmos (Columbia University Medical Center), Roy S. Herbst (Yale School of Medicine), and Suresh S. Ramalingam (Emory University)

    Recent treatment advances in lung cancer supported by a better understanding of genetic heterogeneity may increase survival rates.

    eBriefing

    Systems Biology Approaches to Secondary Metabolites and Metabonomics

    Organizers: Manuel X. Duval (Boehringer Ingelheim Pharmaceuticals; University of New Haven), Thomas B. Freeman (Boehringer Ingelheim Pharmaceuticals), and Jennifer Henry (The New York Academy of Sciences)
    Speakers: Sean F. Brady (The Rockefeller University), Steven Edgar (Massachusetts Institute of Technology), Justin Nodwell (University of Toronto, Canada), and Kang Zhou (Massachusetts Institute of Technology)

    This eBriefing explores a systems biology approach to secondary metabolites and their networks, looking at their biological effects and potential benefits for human health.

  • Podcasts

    Podcast
    April 2, 2010

    More than a Yogurt Cup

    Delve into the world of prebiotic and probiotic science. We talk to three people in the field and learn why keeping the good microbes in our bodies happy means a lot for health.

    Download (14 MB, 00:21:21)
    Podcast
    January 15, 2010

    Feeling the Light

    Researchers at Harvard have discovered why the headaches of some migraine sufferers worsen when the person is exposed to light. Rami Burstein, the study's senior author, explains what's happening in the brain, and how they made the breakthrough.

    Download (15 MB, 00:22:48)
    Podcast
    December 18, 2009

    No Small Matter

    We sit down with science photographer Felice Frankel and nanotechnology pioneer and Harvard chemist George Whitesides to hear about their new book on nanoscience, No Small Matter.

    Download (11 MB, 00:18:04)
    Podcast
    October 16, 2009

    Looking for the Key in P53

    Visit the lab of Hunter College's Jill Bargonetti, a biologist researching cancer. Her team studies P53, a natural tumor-suppressor protein found in our bodies with a Dr. Jekyll and Mr. Hyde personality.

    Download (11 MB, 00:17:20)
  • Webinar Archives

    Webinar Archive
    February 23, 2010

    Metabotropic Glutamate Receptors: Translation from Discovery to Clinical Trials

    Researchers met to discuss advances in basic and translational research on metabotropic glutamate receptors, which are promising targets in drug discovery for CNS diseases and other illnesses.

    Webinar Archive
    October 27, 2009

    Is Alzheimer's Disease Type 3 Diabetes?

    What is the connection between dysregulated neuronal insulin signaling and Alzheimer's disease? In a recent Academy webinar, some researchers argued that the neurodegenerative disease should be considered a type of diabetes.

    Webinar Archive
    April 28, 2009

    Protein Kinases: Structure-Guided Drug Discovery

    Protein kinases play a key role in almost every major pathway in eukaryotic cells. Structural approaches, including a new method called fragment-based drug design, are identifying potential targets against diseases including cancer.

  • Translational Medicine Initiative

    Macy FoundationThe Translational Medicine Initiative represents a three-year partnership between the New York Academy of Sciences and the Josiah Macy, Jr. Foundation to support the translation of basic science research into clinical applications.

    Learn more at www.nyas.org/TransMed.