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  • Cell & Molecular Biology

  • Events 

    Monday, November 3, 2014 | 8:00 AM - 4:30 PM

    Gene Network Changes in Alzheimer's Disease: Potential Points for Therapeutic Intervention

    Speakers: Kwame O. Affram (Uniformed Services University), Erik H.W.G.M. Boddeke (University Medical Center Groningen), Oleg Butovsky (Brigham and Women's Hospital and Harvard Medical School), Philip L. De Jager (Harvard University and Brigham and Women's Hospital), Joseph El Khoury (Massachusetts General Hospital and Harvard Medical School), Miriam Merad (Icahn School of Medicine at Mount Sinai), Michael C. Oldham (University of California, San Francisco), Vishal Sahni (Eisai Inc), Bin Zhang (Icahn School of Medicine at Mount Sinai)

    Next generation sequencing of Alzheimer’s disease (AD) progression reveals gene networks within microglial pathways. This symposium focuses on microglia biology, molecular signatures specific to microglial phenotypes, and phenotype modulation.

    Monday, December 1, 2014 | 1:30 PM - 4:30 PM

    Genome Integrity Discussion Group Meeting

    Speakers: Sevinc Ercan (NYU), Shelley Berger (University of Pennsylvania), Laura Landweber (Princeton University), Xiaolan Zhao (Memorial Sloan-Kettering Cancer Center)

    The Genome Integrity Discussion Group provides a forum for interactions between basic and clinical research groups working on chromosome biology and function, and at the interface between chromosome integrity and onset and progression of malignancy.

    Tuesday, December 9, 2014 | 8:00 AM - 5:00 PM

    Diabetic Kidney Disease: Drug Discovery and Clinical Development Challenges

    Speakers: Matthew D. Breyer (Eli Lilly, Indianapolis, IN), Frank C. Brosius (University of Michigan Medical School, Ann Arbor, MI), Benjamin D. Humphreys (Harvard Institutes of Medicine, Boston, MA), Matthias Meier (F. Hoffmann-LaRoche Ltd, Basel, Switzerland), Shahnaz Shahinfar (S. Shahinfar Consulting, Inc. and The Children's Hospital of Philadelphia), Katalin Susztak (University of Pennsylvania, Philadelphia, PA), Aliza Thompson (US Food & Drug Administration, Silver Spring)

    Identifying and prosecuting drug targets is challenging due to a poor understanding of pathogenesis and few biomarkers. This symposium identifies targets for preventive or therapeutic interventions and discusses challenges in clinical development.

    Tuesday, January 27, 2015 | 8:30 AM - 4:30 PM

    Growing Pains: The Future of Cytokines as Immunotherapies for Oncology, Infection and Inflammatory Disease

    Keynote Speaker: James W. Mier (Beth Israel Deaconess Medical Center/ Harvard Medical School)
    Speakers: Stephen D. Gillies (Provenance Biopharmaceuticals, Carlisle MA), Dario Neri (Philogen, Zurich, Switzerland), Gilles Uzé (Université Montpellier II, Montpellier, France), K. Dane Wittrup (Massachusetts Institute of Technology)

    Systemic toxicity currently prevents exploiting the potential of many cytokines to treat cancer, viral infections, inflammatory and autoimmune conditions. Targeted delivery of immune-stimulatory or immune-regulatory cytokines offers much promise.

    Monday, February 2, 2015 | 1:30 PM - 4:30 PM

    Genome Integrity Discussion Group Meeting

    Speakers: Prasad Jallepalli (Memorial Sloan-Kettering Cancer Center), Susan Smith (NYU Langone Medical Center), Iestyn Whitehouse (Memorial Sloan-Kettering Cancer Center), John Petrini (Memorial Sloan-Kettering Cancer Center)

    The Genome Integrity Discussion Group provides a forum for interactions between basic and clinical research groups working on chromosome biology and function, and at the interface between chromosome integrity and onset and progression of malignancy.

  • Past Events

    Tuesday, October 28, 2014 | 8:30 AM - 5:00 PM

    Pharmacologic Resolution of Inflammation as a Novel Therapeutic Approach

    Speaker: Michael S. Conte (University of California-San Francisco), Milan Fiala (David Geffen School of Medicine at UCLA), Gabrielle Fredman (Columbia University), Bruce Levy (Harvard University, Brigham and Women's Hospital), Dipak Panigrahy (Beth Israel Deaconess Medical Center, Harvard Medical School), Mauro Perretti (Queen Mary University of London), Charles N. Serhan (Brigham & Women's Hospital, Harvard Medical School), Patricia J. Sime (University of Rochester School of Medicine), Rudolph E. Tanzi (Massachusetts General Hospital)

    Uncontrolled, chronic inflammation plays a key role in the progression of many diseases, and elucidation of biochemical pathways provides novel targets. This symposium reviews discoveries, approaches and opportunities for treatment and prevention.

    Thursday, October 9, 2014 | 8:00 AM - 4:00 PM

    Targeting Key Vulnerabilities in Pancreatic Cancer

    Keynote Speakers: Neesha Dhani (Princess Margaret Hospital, Toronto), Steven D. Leach (Memorial Sloan Kettering Cancer Center)
    Speakers: Gregory Beatty (University of Pennsylvania Perelman School of Medicine), Neesha C. Dhani (Division of Medical Oncology & Hematology, University Health Network, Princess Margaret Cancer Centre/Ontario Cancer Institute), Mikala Egeblad (Cold Spring Harbor Laboratory), Douglas T. Fearon (Weill Cornell Medical College and Cold Spring Harbor Laboratory), Elda Grabocka (Department of Biochemistry and Molecular Pharmacology, NYU Langone School of Medicine), Costas A. Lyssiotis (Weill Cornell Medical College ), George Miller (NYU Langone Medical Center), Michael Ports (Gilead Sciences), Curtis B. Thompson (Halozyme Therapeutics, Inc)

    Pancreatic cancer patients currently have limited therapeutic options. This symposium explores breakthroughs in the pathogenesis and progression of pancreatic cancer, and efforts to exploit key vulnerabilities for novel therapeutic interventions.

    Monday, October 6, 2014 | 1:30 PM - 4:30 PM

    Genome Integrity Discussion Group Meeting

    Speakers: Jane Skok (NYU), Agnel Sfeir (NYU), Eli Rothenberg (NYU), Lorraine Symington (Columbia University Medical Center)

    The Genome Integrity Discussion Group provides a forum for interactions between basic and clinical research groups working on chromosome biology and function, and at the interface between chromosome integrity and onset and progression of malignancy.

    Tuesday, September 30, 2014 | 8:30 AM - 5:00 PM

    Elucidating GPCR Functional Selectivity: Novel Opportunities for Drug Development

    Keynote Speaker: Nobel Laureate Robert J. Lefkowitz (Duke University Medical Center)
    Speakers: John A. Allen (Pfizer), Laura Bohn (The Scripps Research Institute - Florida), Marc G. Caron (Duke University Medical Center), Jonathan A. Javitch (Columbia University and New York State Psychiatric Institute), Terry Kenakin (University of North Carolina School of Medicine), Bryan L. Roth (University of North Carolina School of Medicine), JoAnn Trejo (University of California, San Diego), Jonathan D. Violin (Trevena Inc.)

    Hear academic, industry, basic and translational researchers, including Nobel Laureate Robert Lefkowitz (Duke University Medical Center) and discuss the development of functionally selective GPCR-biased ligands for CV and CNS disease drug discovery.

  • Publications 

    Annals

    Addiction Reviews

    Edited by George R. Uhl (National Institutes of Health, Baltimore, Maryland)

    The sixth installment of this annual series explores molecular and translational/therapeutic aspects of addiction.

    Volume 1327

    eBriefing

    Fifty Years of the Genetic Code: Honoring the Legacy of Marshall Nirenberg

    Organizers: C. Thomas Caskey (Baylor College of Medicine), Brian Clark (University of Aarhus, Denmark), Gregory A. Petsko (Weill Cornell Medical College), and Jennifer Henry (formerly at The New York Academy of Sciences)

    The identification of the genetic code has offered many opportunities for further scientific discovery. This eBriefing honors the legacy of Nobel laureate Marshall Nirenberg, who described the basic unit of the genetic code 50 years ago.

    Annals

    The 12th OESO World Conference: Cancers of the Esophagus

    Edited by Robert Giuli (Deputy Director of OESO, Executive Director of the OESO Foundation, Paris, France) and Asad Umar (National Cancer Institute, Rockville, Maryland)

    This Annals volume presents a compilation of expert views on topics related to esophageal cancers presented at the World Organization for Specialized Studies on Diseases of the Esophagus 12th World Conference.

    Volume 1325

    eBriefing

    Demyelination and Remyelination: From Mechanism to Therapy

    Keynote Speaker: Robin Franklin (Wellcome Trust – MRC Cambridge Stem Cell Institute, University of Cambridge)

    This eBriefing highlights biological and clinical findings in remyelination. It also features new techniques for imaging myelin and screening molecular targets, as well as therapeutics that promote remyelination.

  • Podcasts

    Podcast
    September 10, 2010

    What Makes Us Wise?

    Can we all be wise old owls? Science journalist Stephen Hall and neuroscientist Andre Fenton dissect what we call wisdom, from the neurons in our brain, to the social constructs behind it.

    Download (22 MB, 00:42:32)
    Podcast
    July 30, 2010

    Oxidative Stress

    Foods high in antioxidants are believed to fight oxidative stress. But what is oxidative stress? Two scientists from a recent NYAS conference break it down and discuss whether antioxidants have superpowers.

    Download (12 MB, 00:18:37)
    Podcast
    July 2, 2010

    What's that Smell?

    Biologist Stewart Firestein and world-renowned perfumer Christophe Laudamiel team up to tackle the science of smell.

    Download (32 MB, 00:49:12)
    Podcast
    April 2, 2010

    More than a Yogurt Cup

    Delve into the world of prebiotic and probiotic science. We talk to three people in the field and learn why keeping the good microbes in our bodies happy means a lot for health.

    Download (14 MB, 00:21:21)
  • Webinar Archives

    Webinar Archive
    February 23, 2010

    Metabotropic Glutamate Receptors: Translation from Discovery to Clinical Trials

    Researchers met to discuss advances in basic and translational research on metabotropic glutamate receptors, which are promising targets in drug discovery for CNS diseases and other illnesses.

    Webinar Archive
    October 27, 2009

    Is Alzheimer's Disease Type 3 Diabetes?

    What is the connection between dysregulated neuronal insulin signaling and Alzheimer's disease? In a recent Academy webinar, some researchers argued that the neurodegenerative disease should be considered a type of diabetes.

    Webinar Archive
    April 28, 2009

    Protein Kinases: Structure-Guided Drug Discovery

    Protein kinases play a key role in almost every major pathway in eukaryotic cells. Structural approaches, including a new method called fragment-based drug design, are identifying potential targets against diseases including cancer.

  • Translational Medicine Initiative

    Macy FoundationThe Translational Medicine Initiative represents a three-year partnership between the New York Academy of Sciences and the Josiah Macy, Jr. Foundation to support the translation of basic science research into clinical applications.

    Learn more at www.nyas.org/TransMed.