Organizers: Jerome Kim (Walter Reed Army Institute of Research), Yegor Voronin (Global HIV Vaccine Enterprise), and Jennifer Henry (The New York Academy of Sciences)Presented by the Vaccine Science Discussion Group
Reported by Judy Keen | Posted July 17, 2012
The quest to develop an effective HIV vaccine began nearly 30 years ago. Now, after several disappointing attempts, positive results are emerging. In 2009, the RV144 clinical trial in Thailand was the first successful trial of an HIV vaccine, achieving a 31% reduction in the rate of new HIV infections using a novel protocol combining two single agent vaccines. In the 3 years since this trial researchers have begun to unravel the vaccine's mode of action and to understand key mechanisms underlying its success. These new analyses offer clues into how to develop a better, more targeted HIV vaccine that will eliminate infection in a broad population.
The HIV / AIDS Update: Prevention, Treatment, and Beyond symposium, presented on May 11, 2012 by the Academy's Vaccine Science Discussion Group, focused on efforts to improve vaccine design, based on results from the clinical trials and on new information about the structure of the viral envelope protein. Researchers presented work on the roles of neutralizing and non-neutralizing antibodies in protecting against HIV, and discussed the use of non-human primate models in the design and testing of vaccines. Presenting updates on the search for a cure for AIDS, researchers discussed the challenge of eliminating viral reservoirs and reported on using improved humanized mice models to study novel therapeutics. The symposium drew attention to future directions for HIV vaccine research and ended with a spirited mock debate over whether the first FDA-approved HIV vaccine would be a neutralizing or non-neutralizing antibody vaccine; highlighting the importance of antibodies in HIV infection and the challenges involved in developing a successful HIV vaccine.
Use the tabs above to find a meeting report and multimedia from this event.
Presentations available from:
Dan H. Barouch, MD, PhD (Beth Israel Deaconess Medical Center, Harvard Medical School)
Timothy Cardozo, MD, PhD (NYU School of Medicine)
Nicolas Chomont, PhD (Vaccine & Gene Therapy Institute of Florida)
Donald Forthal, MD (University of California, Irvine, School of Medicine)
J. Victor Garcia-Martinez, PhD (University of North Carolina, Chapel Hill)
Nelson L. Michael, MD, PhD (Walter Reed Army Institute of Research)
Christopher J. Miller, DVM, PhD (University of California, Davis)
Alan M. Schultz, PhD (NIAID, NIH)
This program is supported by an educational grant from Gilead Sciences, Inc.