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COLUMNS The Information Age • The Electronic Palimpsest Digital documents for all occasions: erasable, reproducible, forgeable BRIAN HAYES
ESSAYS & COMMENT Cover Story • A Plague Returns TB is back, the grim harvest of decades of complacency. The greatest fear is a multiple-drug-resistant form treatable only through quarantine. MARK EARNEST AND JOHN A. SBARBARO
FEATURES The Sound of Oceans Warming Acoustic signals have been sent halfway around the world through a natural underwater sound channel. The goal is to measure the global greenhouse effect. WALTER MUNK
Brain by Design An era of molecular engineering, aimed at refining and refocusing the effects of marijuana and other psychoactive drugs, may be at hand RICHARD RESTAK
The Stuff of Stars When a woman graduate student discovered abundant hydrogen in stellar spectrums, she was bullied into suppressing her results results MARCIA BARTUSIAK
REVIEWS The Holy Grail of Physics TIs the end of physics in sight? How would anyone recognize a complete physical theory if one were thrust upon us? LAWRENCE KRAUSS
Books in Brief • The Emir of Arithmetic PLUS: Alternative medicine; a forensic anthropologist looks at bones LAURENCE A. MARSCHALL
DEPARTMENTS Initial Conditions • Editor's Notebook
Peer Review Letters from Readers
Quanta Fermat's last theorem falls to Andrew Wiles; mechanisms of migraine; the short shelf life of videotape
Strange Matter As Yet to Be Proven ROZ CHAST
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