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COLUMNS The Information Age • Eureka! Forget the needle in the haystack. Modern searchers often don't know what they're looking for until they have found it BRIAN HAYES
Heat Exchange • Q & A: Bush vs. Gore The two major presidential candidates reply to questions from The Sciences on science and technology policy CONDUCTED BY IRWIN GOODWIN
ESSAYS & COMMENT Cover Story • Defense Mechanisms Neither President Clinton's National Missile Defense nor George W. Bush's even more ambitious system would be technically capable of shielding the United States against a missile attack KOSTA TSIPIS
FEATURES Oral Reports Dentistry is shifting its emphasis from drill and fill to antibiotics and biotechnology. For the patient, that is a future to smile about ROBERT J. GENCO, FRANK A. SCANNAPIECO AND HAROLD C. SLAVKIN
More Than Meets the Eye Ninety-five percent of the cosmos is made up of mysterious dark matter that holds tha galaxies together and dark energy that drives the universe apart MICHAEL S. TURNER
REVIEWS Naked Ambition The TV blockbuster Survivor as a test bed for thinking about political and economic strategy ALEXA JERVIS AND ROBERT JERVIS
Books in Brief • Ceaseless Efforts PLUS: Treasures of Madagascar; grand old man of astronomy LAURENCE A. MARSCHALL
DEPARTMENTS Initial Conditions • Editor's Notebook WInners and Losers PETER G. BROWN
Peer Review Letters from Readers
Working Hypotheses • Mr. Jefferson and Mr. Moore RODNEY W. NICHOLS
Quanta When sperm meets egg; learning from smallpox
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