• Systems Biology Discussion Group

    High-throughput biotechnology and information technology have generated an overwhelming amount of information about genes, proteins, and other cellular entities. This remarkable success story has also created a pressing need to make sense of a plethora of biological facts. Systems biology is an attempt to infer networks of interactions of cellular components from such biological data, and then to build accurate predictive models of them.

    The Systems Biology Discussion Group promotes interaction between biologists and computational scientists so that researchers are armed with both the experimental tools of modern molecular biology and the analytical methodologies of math, physics, computer science, and engineering. Meetings focus on efforts to model basic mechanisms of cellular function and on practical applications for systems biology approaches.

  • Past Events

    Thursday, March 20, 2014 | 6:00 PM - 8:30 PM

    Systems Biology Approaches to Secondary Metabolites and Metabonomics

    Speaker: Sean F. Brady (The Rockefeller University), Steven Edgar (MIT), Justin Nodwell (University of Toronto), Kang Zhou (MIT)

    Secondary metabolites or idiolites play many roles in biological systems, including communication, defense and signaling. This symposium takes a systems biology approach to explore their biological effects and potential benefits for human health.

    Thursday, December 6, 2012 | 6:00 PM - 8:30 PM

    Cancer Cell Metabolism and Systems Biology

    Speakers: Jason Locasale (Cornell University), Vamsi K. Mootha (Broad Institute of MIT and Harvard Medical School), Carol Prives (Columbia University)

    The role of cell metabolism in cancer and the regulation of nutrient and energy signaling networks remain a mystery. This symposium explores cellular machinery cross-talk using a systems biology approach to explore cell growth, cancer and metabolism.

    Thursday, October 11, 2012 | 6:00 PM - 8:30 PM

    Dynamics of Immune Cell Communication Networks

    Speakers: Debashis Barik (Memorial Sloan-Kettering Cancer Center), Christine Grimaldi (Boehringer-Ingelheim), Nir Hacohen (Massachusetts General Hospital, Broad Institute and Harvard Medical School)

    The immune response deters dangerous intruders, but when it fails, can lead to autoimmune ailments, ineffective immunotherapies and adverse reactions to biological therapies. This symposium examines the behavior of this complex, dynamic network.

    Tuesday, January 17, 2012 | 4:45 PM - 7:30 PM

    Single-Cell Level Systems Biology

    Organizers: Andrea Califano (Columbia University), Manuel Duval (Network Therapeutics Inc.), Aris Economides (Regeneron Pharmaceuticals), Gustavo Stolovitzky (IBM Research), Jennifer Henry (The New York Academy of Sciences)
    Speakers: Narendra Maheshri (Massachusetts Institute of Technology), Johan Paulsson (Harvard Medical School), Chris Wiggins (Columbia University), Grégoire Altan-Bonnet (Memorial Sloan-Kettering Cancer Center)

    Fluorescence microscopy advances have opened new vistas in the study of the dynamics of molecules in single cells. This symposium brings together systems biologists working on the elucidation of the effects of noise in single cells using mathematical and experimental methods.

    Monday, October 24, 2011 | 5:00 PM - 7:30 PM

    The Reactivity of the Cellular Transcriptome to Xenobiotic Compound Perturbation

    Speakers: Duane C. Hassane (Weill Cornell Medical College), Rui-Ru Ji (Bristol-Myers Squibb) and Arvind Subramanian (Broad Institute of MIT and Harvard University)

    The transcriptome of the cell is dynamic, and varies according to chemical perturbations. This symposium will explore connectivity maps, dose-dependent transcriptome responses, characterization of drug activity and chemical genomics in cancer.

    Tuesday, June 14, 2011 | 5:00 PM - 7:30 PM

    How Do Cells React to Drugs? A Systems Biology Perspective

    Speakers: Andrea Califano (Columbia University), Ravi Iyengar (Mount Sinai School of Medicine) and Joseph Lehár (Novartis Institutes for BioMedical Research)

    Systems biologists and pharmacologists come together in the quest to develop new drugs. This symposium applies a systems biology approach to elucidate context-specific mechanisms of drug response and sensitivity.

    Friday, May 6, 2011 | 5:00 PM - 7:30 PM

    Systems Biology and New-Generation Sequencing Technologies

    Speakers: Thomas R. Gingeras (Cold Spring Harbor Laboratory), Manolis Kellis (MIT), and Gustavo Stolovitzky (IBM Research)

    Systems and computational biologists collaborate to integrate high-throughput biological data and new sequencing technologies. This reveals previously unexplored genomic features such as functional intergenic regions, and copy number variations.

    Monday, March 7, 2011 | 5:00 PM - 7:30 PM

    The Systems Biology of Aging and Neurodegenerative Diseases

    Speakers: Domenico Accili (Columbia University), David Galas (Institute for Systems Biology, Seattle, WA) and David T. Burke (Institute of Gerontology, University of Michigan)

    Systems and computational biologists combine methodologies to examine aging and neurodegenerative diseases, covering genetics and the development and application of new technologies, to increase our understanding of these complex biological networks.

    Monday, November 8, 2010 | 5:00 PM - 7:30 PM

    The Systems Biology of Bugs

    Speakers: Richard Bonneau (New York University), Yuhai Tu (IBM T.J. Watson Research Center) and Saeed Tavazoie (Princeton University)

    Systems biologists and computational biologists combine methodologies to examine bacterial genomes and elucidate basic signal transduction mechanisms and the genetic basis of phenotypes in bacteria of biological, environmental and clinical importance.

    Thursday, June 10, 2010 | 5:00 PM - 7:30 PM

    A Look at the Tools and Comparative Approaches of Systems Biology

    Speakers: Mark Gerstein (Yale University), Avi Ma’ayan (Mount Sinai School of Medicine), and Stefano Monti (The Broad Institute)

    Systems Biology tools such as modeling, algorithms and machine-learning techniques are used to unravel the complexity of regulatory networks, analyze genomics data, perform integrative surveys and mine protein and gene regulatory networks.

    Wednesday, May 12, 2010 | 9:00 AM - 6:00 PM

    Herbert Irving Comprehensive Cancer Center Annual Symposium: "Cancer Systems Biology"

    Speakers: Andrea Califano (Columbia University Medical Center), James R. Downing (St. Jude Children's Research Hospital), Joe W. Gray (Lawrence Berkeley National Laboratory/UCSF), Antonio Iavarone (Columbia University Medical Center), Douglas A. Lauffenburger (Massachusetts Institute of Technology), Arnold J. Levine (Institute for Advanced Study/CINJ at UMDNJ-RWJMS), Leona D. Samson (Massachusetts Institute of Technology), Chris Sander (Memorial Sloan-Kettering Cancer Center), and Marc Vidal (Dana Farber Cancer Institute/Harvard Medical School)

    This meeting brings together researchers using systems biology to interrogate the networks underlying multiple cancers, model their perturbations, and identify novel candidate targets for diagnostic and therapeutic intervention.

    Tuesday, March 16, 2010 | 5:00 PM - 7:30 PM

    A Systems Approach to Studying Host-Pathogen Relationships

    Speakers: Steve Kleinstein (Yale University), Gustavo Palacios (Mailman School of Public Health - Columbia University) and Raul Rabadan (Columbia University College of Physicians and Surgeons)

    This symposium covers the use of systems biology tools, genome analysis and bioinformatics, to better understand the host-pathogen relationships and the immune response.

    Thursday, November 19, 2009 | 5:00 PM - 7:30 PM

    Systems Biology Meets Developmental Biology

    Speakers: Angela DePace (Harvard Medical School), Stanislav Y. Shvartsman (Princeton University) and Antonio Iavarone (Columbia University)

    This symposium focuses on computational, quantitative imaging and genetic approaches to understand patterning and morphogenesis, and the gene regulatory networks that control development and evolution.

  • Steering Committee

    Andrea Califano, PhD

    Columbia University

    Manuel Duval, PhD

    Boehringer-Ingelheim and University of New Haven

    Aris Economides, PhD

    Regeneron Pharmaceuticals

    Thomas B. Freeman, MS


    Pablo Meyer, PhD

    IBM Research

    Gustavo A. Stolovitzky, PhD

    IBM Research