Skip to main content


Search


Search Results for: "Janssen Award"



Advancing Tyrosine Kinase Inhibitors from Discovery to Patient Care: The Dr. Paul Janssen Award Symposium

Video

The Dr. Paul Janssen Award Symposium celebrated the groundbreaking achievements of Dr. Anthony “Tony” Hunter, PhD, American Cancer Society Professor and Renato Dulbecco Chair at the Salk Institute for Biological Studies in La Jolla, California. This symposium brought together leading voices in cancer research and biomedical innovation to honor Dr. Hunter’s pioneering work and explore its profound impact on modern science and […]


Advancing Tyrosine Kinase Inhibitors from Discovery to Patient Care: The Dr. Paul Janssen Award Symposium

Event

The Dr. Paul Janssen Award Symposium will celebrate the groundbreaking achievements of Dr. Anthony “Tony” Hunter, PhD, American Cancer Society Professor and Renato Dulbecco Chair at the Salk Institute for Biological Studies in La Jolla, California. Dr. Hunter is being honored for his pioneering discovery of tyrosine kinases and protein-tyrosine phosphorylation as mechanisms for the malignant transformation of normal cells into […]



Regulated Degradation of RNA and Proteins: The Dr. Paul Janssen Award Symposium

Event

Lynne Maquat, PhD, of the University of Rochester and Alexander Varshavsky, PhD, of the California Institute of Technology have been awarded the prestigious 2024 Dr. Paul Jannsen Award for their fundamental discoveries in the regulated degradation of RNAs and proteins. Dr. Maquat’s research has unveiled how cells selectively destroy flawed messenger RNA molecules to prevent the […]



Therapeutic Promise of the Microbiome: The Dr. Paul Janssen Award Symposium

Event

Developing targeted therapies for rare cardiomyopathies is challenging: difficulties identifying patients, delivering therapeutics, and accessing heart tissue results in a 50% mortality rate 5 years after diagnosis.  Early, accurate disease detection and classification can significantly improve outcomes for patients with rare cardiomyopathies. Achieving these goals requires multiple novel technologies to coalesce that will enable early […]


Pioneering Novel Drug Delivery Systems: The Dr. Paul Janssen Award Symposium

Event

Since 2004, the Dr. Paul Janssen Award for Biomedical Research has honored scientists who have made a transformational contribution toward the improvement of human health. This prestigious award honors the legacy of Dr. Paul Janssen, an exceptionally gifted and passionate scientist who revolutionized modern medicine and inspired a new generation of researchers. This half-day virtual […]


Linking Metabolism, Health, and Cancer: 2020 Dr. Paul Janssen Award Symposium

Ebriefing

Lewis C. Cantley’s discovery of the enzyme phosphatidylinositol-3-kinase (PI3K) paved the way for a better understanding of cellular metabolism and its role in human diseases. In response to insulin, PI3K signals through lipids to activate a cellular cascade resulting in increased glucose uptake and subsequent cell growth and division. Cantley’s work has led to new cancer […]


Protein Folding in Human Health: 2019 Dr. Paul Janssen Award Symposium

Ebriefing

Mammalian cells can make up to 20,000 different proteins, which are responsible for a wide range of cellular functions, including structure, catalysis, transport, and signaling. Proteins are synthesized as linear chains, but to carry out their myriad roles, they must then fold into complex three-dimensional configurations.

Franz-Ulrich Hartl, MD, of the Max Planck Institute of Biochemistry and Arthur Horwich, MD, of Yale School of Medicine and Howard Hughes Medical Institute, have dedicated their careers to better understanding the molecular machinery that drives protein folding, and the implications when a protein misfolds. In doing so, they discovered a new class of proteins, part of the chaperone family, responsible for protein folding.


The Hunter of Tyrosine Kinases

Blog Post

“The study of tumor viruses and their oncogenes really led to a revolution in our understanding of cancer.”


RESULTS FROM ANNALS


October 01, 2026  · 
Structure of Musical Dislikes: Findings From Multiple Genres and Countries
Contributors: Julia Merrill| Klaus Frieler| Amanda E. Krause|
Abstract: Musical taste shapes social life and personal identity, yet research has focused mainly on why pe...
Read More  

September 24, 2026  · 
Initial Evidence of Mathematics Interpretation Bias Intervention Effects on College Students’ Mathematics Anxiety
Contributors: Connie Barroso| Xiaotong Yi| Zhe Wang|
Abstract: Cognitive bias modification of interpretation bias (CBM‐I) can significantly reduce negatively bi...
Read More  

September 24, 2026  · 
Dynamic Adaptation Responses to Auditory Perturbations During Walking in Multiple Sclerosis With Progressive Subtypes
Contributors: Lousin Moumdjian| Joeri R. Verbiest| Nele Vanbilsen| Bart Moens| Mattia Rosso| Daphne Kos| Bart Van Wijmeersch| Peter Feys|
Abstract: Walking requires adaptation to dynamic environmental demands, yet how persons with progressive mu...
Read More  

September 22, 2026  · 
Infant Imitation and Rhythmic Movement in Response to Music and Speech
Contributors: Haley E. Kragness|
Abstract: Humans move our bodies to rhythms. This behavior is developmentally precocious: infants and young...
Read More  

September 22, 2026  · 
Female Budgerigars Attend Equally to Rhythmic Beat or Repetition, While Humans Prioritize Their Combination
Contributors: Felix Haiduk| Daniel L. Bowling| Shahrzad Afroozeh| Jan Kopač| Mahin Azarian| Marisa Hoeschele|
Abstract: Rhythm is an essential aspect of human music, typically characterized by temporal regularity of s...
Read More  

September 22, 2026  · 
A Theory of Planned Behavior–Based Cluster Randomized Trial to Improve Health Literacy Among Rural Adults in China
Contributors: Ran Dai| Dingjie Zhou| Xue Wan| Xiaoxuan Xu| Wenhui He| Xiaoxu Guo| Hongyan Tang| Hua You|
Abstract: Rural populations often face structural barriers to accessing, interpreting, and using health inf...
Read More  

September 21, 2026  · 
Pain Modulates Optimism‐Biased Belief Updating and Confidence
Contributors: Penggeng Zhao| Cuizhen Liu|
Abstract: Optimism‐biased belief updating—the tendency to update beliefs more strongly in response to desir...
Read More  

September 18, 2026  · 
FreqPolyp: Single‐Source Domain Generalization for Polyp Segmentation via Amplitude Decoupling and Wavelet Cross‐Attention
Contributors: Xi Huang| Yuling Yang| Xun Zhang| Yanxia Zhang| Hong Zeng|
Abstract: Accurate segmentation of colorectal polyps is important for colorectal cancer prevention. However...
Read More  

September 17, 2026  · 
Atypical Inter‐Brain Synchrony Network Couples With Behavioral and Linguistic Impairments in Autism Spectrum Disorder
Contributors: Yuhang Li| Yiting Zhu| Yingbo Geng| Danyong Feng| Shuo Guan| Dongyun Li| Yingchun Zhang| Lianni Mei| Xingyu Ding| Qiong Xu| Rihui Li|
Abstract: Social difficulty is a core phenotype of autism spectrum disorder (ASD), yet its mechanisms remai...
Read More  

September 17, 2026  · 
Social Connection and Epigenetic Aging: Insights from DNA Methylation Clocks
Contributors: Feifei Bu| Daisy Fancourt|
Abstract: Social connection is increasingly recognized as a determinant of healthy aging, yet the biologica...
Read More  

September 16, 2026  · 
Urea‐Predoped, KOH‐Activated, Corn Stover–Derived Carbon for CO2 Adsorption
Contributors: Yize Dang| Zilong Chen| Chengzhuang Zhang| Zhiqiang Han| Zinong Zuo| Kun Liang| Jia Fang|
Abstract: The rising concentration of greenhouse gases causes severe global warming, creating an urgent nee...
Read More  

September 15, 2026  · 
ARMOR: Pareto‐Aware Dynamic Routing for Energy‐Efficient Heterogeneous Multimodal Perception in Autonomous Driving
Contributors: Junli Liu| Yinggui Zhang| Yanzhan Chen| Yue Wang|
Abstract: Modern autonomous driving systems are constrained by the tension between high‐fidelity perception...
Read More  

September 14, 2026  · 
Intra‐Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia
Contributors: Samaneh Fatehi| Jonathan V. Rocheleau| Michael C. Riddell|
Abstract: The regulation of glucagon and insulin secretion, from pancreatic α‐ and β‐cells, respectively, i...
Read More  

September 12, 2026  · 
A Two‐Stage Grip Force Estimation Method for Surgical Robots Based on BiLSTM‐iTransformer
Contributors: Tiecheng Su| Mingzhang Pan| Lu Liang| Chun Ma| Yu Cai| Weizhe Feng| Ke Liang|
Abstract: In robot‐assisted minimally invasive surgery, precise grasping force feedback is a key factor for...
Read More  

September 12, 2026  · 
Digital Balance Biomarkers and Interpretable Evaluation of Disease Severity in Spinocerebellar Ataxia Type 3
Contributors: Yue Zhang| Yuanyuan Xiao| Kai‐Liang Luo| Wei Lin| Wanli Zhang| Xia Liu| Qi‐Kui Sun| Ru‐Ying Yuan| Jun Ni| Shi‐Rui Gan| Xin‐Yuan Chen|
Abstract: The clinical assessment of spinocerebellar ataxia type 3 (SCA3) is hindered by subjective factors...
Read More  

September 11, 2026  · 
Individual and Contextual Socioeconomic Position on Type 2 Diabetes Risk in LMICs: A Multilevel Analysis
Contributors: Reza Fahimi| Abdulaziz Alrubayyi| Muntaha Hassan| Thomas M. Barber| Olalekan A. Uthman|
Abstract: Type 2 diabetes mellitus (T2DM) represents a growing public health challenge in low‐ and middle‐i...
Read More  

September 10, 2026  · 
PIEZO1 Mediates Myoblast Proliferation Under Simulated Microgravity
Contributors: Yizhou Liu| Xiaojian Cao| Danxia Huang| Hongmei Luo| Song Zhang| Yujie Yang| Qiuzhi Zhou| Yajie Li| Jia Xu| Hong Chen|
Abstract: Skeletal muscle atrophy is a major health risk of prolonged spaceflight, yet how microgravity res...
Read More  

September 10, 2026  · 
Critical Review on the Development and Evolution of Beat Perception
Contributors: Gábor Háden| Henkjan Honing|
Abstract: Beat perception—the ability to extract a regular pulse from rhythmic sequences—is a foundational ...
Read More  

September 09, 2026  · 
HMM‐PMM: A Parallel Hidden Markov Model‐Based Map‐Matching Framework for Large‐Scale Trajectory Data
Contributors: Ruibo Cong| Bozhao Li| Zhengjia Niu| Zhongliang Cai| Wentao Cao|
Abstract: Map‐matching algorithms are commonly used for trajectory position correction in offline trajector...
Read More  

September 04, 2026  · 
A Residual Spatial Attention Graph Network for Sensorless Force Estimation in Teleoperated Robots
Contributors: Ke Liang| Yu Cai| Weizhe Feng| Kui Wang| Yue Su| Mingzhang Pan| Tiecheng Su|
Abstract: Precise force feedback is essential for teleoperated robots to perceive unknown environments and ...
Read More