This volume presents reviews that cover a range of topics in addiction science, with authorship from the United States and European Union. The likely inclusion of craving in DSMV criteria for addiction confers special timeliness on the paper from Stephen Tiffany and Jennifer Wray. We can now look back on addiction therapeutics in general and the clinically- and financially-successful anti-addiction medication buprenorphine in the review from Nancy Campbell and Anne Lovell. Marcus Munafò and colleagues provide an important emphasis of the ways in which socioeconomic status interacts with a common addiction, smoking. Ivy Carroll and colleagues provide an excellent update on the medicinal chemistry of new designer drugs that proves his uncanny ability to trace designed drugs from the streets back to the papers in which their syntheses and properties were described. The often under-appreciated role of ultrastructural information in defining circuits important for addiction is reviewed by longtime leaders in this field Marisela Morales and Virginia Pickel. The important continuing contributions of smoking comorbidities are reviewed by Tony George and colleagues, and a framework for mouse models for smoking cessation is discussed a review by Scott Hall, George Uhl, and colleagues.