Annals Reports (3)
Published: December 2014
Volume 1333Learn More
The advancement of next-generation sequencing technologies now enables the landscape of genetic alterations in HNSCCs to be deciphered. This volume also includes a report that describes the mutation spectrum discovered in HNSCCs, especially HPV-associated and/or tobacco smoke exposure–associated HNSCCs. Related research is described from two independent investigators and from the Cancer Genome Atlas. Emphasis is placed on the therapeutic implications of genes frequently altered in HNSCCs and their corresponding pathways, with a particular focus on recent findings of Notch signaling pathway activation in HNSCC. Also discussed is the application of integrated genomic pathway–based analysis for precision cancer therapy in HNSCC.
The third report presented in this volume explores the class of adhesion G protein–coupled receptors (aGPCRs)—the second largest family of GPCRs. All aGPCRs but one (GPR123) contain a GPCR autoproteolysis–inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain–mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. Recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs are discussed.
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