Circulating Nucleic Acids in Plasma and Serum V

Edited by Edited by Peter B. Gahan (King's College, University of London, UK) and R. Swaminathan (Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK)
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Circulating Nucleic Acids in Plasma and Serum V

Published: September 2008

Volume 1137

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DNA and RNA fractions have been isolated from whole blood, serum, plasma, the surface of blood cells, and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders, for example, diabetes, cancer, myocardial infarction, and stroke. The ability to isolate these fractions and assess their relationship to specific diseases makes early noninvasive diagnosis possible. This volume includes chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter cells and exhibit biological activity, isolating and testing fetal cells from maternal blood, and discussing the clinical implications of these discoveries and developing the techniques that will bring them into clinical application.