Annals

Circulating Nucleic Acids in Plasma or Serum

Edited by Edited by Philippe Anker and Maurice Stroun (Pavillon des Isotopes, University of Geneva, Switzerland)
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Circulating Nucleic Acids in Plasma or Serum

Published: April 2000

Volume 906

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Free DNA present in both healthy and diseased human plasma has been found to express specific point mutations that may serve as diagnostic signposts - perhaps to reliable, noninvasive tests for breast and lung cancer, hematopoietic malignancies, colorectal or pancreatic carcinoma, and other tumors. In another research area, fetal DNA has been detected in maternal serum which presents an early-horizon alternative in utero test for gender. A parallel discovery of rearranged immunoglobulin heavy -chain DNA in the plasma of patients with Hodgkin's disease or acute B cell leukemia has also emerged. These fast-emerging indicators suggest that it is time to standardize research techniques and develop protocols that can take a measure of circulating DNA's impact as a new diagnostic tool.

This volume is out of print.