Annals

Drug Addiction

Edited by Edited by Syed F. Ali (National Center for Toxicological Research/FDA, Jefferson, Arkansas) and Michael J. Kuhar (Division of Neuroscience, Yerkes National Primate Research Center of Emory University, Atlanta, Georgia)
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Drug Addiction

Published: October 2008

Volume 1139

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Methamphetamine, MDMA, PMA and different solvents are the most widely abused drugs in Europe, the United States, Central America, South America, and throughout Asia; and their use has dramatically increased over the last two decades. These drugs of abuse are known to cause neurotoxicity in several species, not only rodents, dogs, and nonhuman primates, but also humans. Nevertheless, the precise neurochemical mechanisms underlying this drug-induced neurotoxicity remain unclear. Among other things this volume discusses the roles of genomics, proteomics, and metabonomics in drug-induced neurotoxicity; drugs of abuse and medication development; molecular biology and free radicals in drugs of abuse-induced neurotoxicity; substituted amphetamine-induced neurochemical changes and relationship to neurotoxicity; drug of abuse and imaging brain structure and function; and GHB/volatile solvent/inhalant neurotoxicity.