Annals

Glucocorticoid Action

Edited by Edited by Tomoshige Kino (Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland), Evangelia Charmandari (Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland), and George P. Chrousos (Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland)
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Glucocorticoid Action

Published: June 2004

Volume 1024

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This volume presents the most recent advances in the basic and clinical aspects of glucocorticoid action, in particular, (i) the impact of maternal and early life stress on stress-related gene regulation in the offspring; (ii) the importance of glucocorticoids and their receptors; (iii) further understanding of the mechanisms of GR action, including its effect on chromatin modulation, its interaction with coactivators and corepressors, and the genetic dissection of GR function in mice; (iv) the interaction of hGR with other transcription factors, such as NF-kappa-B, p53, transforming growth factor beta (TGF-beta) and the chicken ovalbumin upstream promoter transcription factor II (COUP-TFII); (v) factors that modulate the function of the GR, including phosphorylation, recycling, ubiquitination and degradation of the receptor, actions of the GR-beta isoform, a novel synthetic nonsteroidal target gene-specific agonist, the importance of target tissue activity of 11-beta-hydroxysteroid dehydrogenase type 1 in glucocorticoid action in health and disease, the interaction of the receptor with the nutrient carnitine, the anthrax products protective antigen (PA) and lethal factor (LF), and the human immunodeficiency virus type-1 (HIV-1)-encoded molecules Vpr and Tat; (vi) an update on the effects of glucocorticoids on the immune system; and (vii) the clinical implications of glucocorticoid action, including glucocorticoid resistance/hypersensitivity, familial and sporadic glucocorticoid resistance, and the effects of stress and depression.