Annals

Glycobiology of the Immune Response

Edited by Edited by Gabriel Rabinovich (Institute of Biology and Experimental Medicine, Buenos Aires, Argentina), Brian Cobb (Case Western Reserve University, Cleveland, Ohio), and Yvette van Kooyk (VU University Medical Center, Amsterdam, the Netherlands).
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Glycobiology of the Immune Response

Published: April 2012

Volume 1253

A comprehensive overview of the role of glycans and lectins in the immune system.
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Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system.