This volume brings together researchers and scholars from both the Indo-Tibetan traditions and the international scientific community to open a dialogue about the potential to build a program of collaborative research to study the impact of Indo-Tibetan practices on longevity and health. A revolution is occurring in the Western science of longevity, regeneration, and health that may increase the potential for extended human lifespan in an optimal state of health. This revolution is being conducted on the molecular, cellular, physiological, and psychological levels. Indo-Tibetan Buddhism claims that its core of meditative, yogic, and related practices can potentially produce dramatic enhancements of physiological and psychological functioning, and a substantial body of Western scientific evidence, including direct and indirect evidence from clinical medicine and basic science research, lends support to many of these claims. The discussions herein establish a basis for a program of research that will advance our current understanding of longevity and health.