Annals

Lysophospholipids and Eicosanoids in Biology and Pathophysiology

Edited by Edited by Edward J. Goetzl (University of California, San Francisco) and Kevin R. Lynch (University of Virginia Health Sciences Center, Charlottesville, Virginia)
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Lysophospholipids and Eicosanoids in Biology and Pathophysiology

Published: April 2000

Volume 905

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The cellular-wide activities of the lipid mediators have made them intrinsic to research on such prevalent cell-based pathologies as obesity, cell immunity, and neural degeneration. The influence of the lysphospholipids and eicosanoid families, especially LPA and S1P, needs to be defined for the progress of research on these important cancer and cardiovascular diseases. These papers and posters focus on lipid biochemistry and eicosanoid generation, and highlight new findings on their roles in nuclear signaling, in cellular proliferation, differentiation, and in cell apoptosis and transformation. Participants' reviews of the psychological effects of the lipids in the nervous, immune and cardiovascular systems lead directly to a statement of current pharmaceutical approaches with small molecule agonists and antagonists that could offer direct results for these critical pubic health problems.

This volume is out of print.