Malaria: Advances in Pathophysiology, Biology, and Drug Development

Edited by Edited by Annals of the New York Academy of Sciences editorial staff
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Malaria: Advances in Pathophysiology, Biology, and Drug Development

Published: April 2015

Volume 1342

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Malaria remains a global health threat, putting an estimated 3.4 billion people at risk for infection. In 2012 alone, approximately 207 million people were diagnosed with malaria, ultimately resulting in 627,000 deaths, most of which occurred in Sub-Saharan Africa. This Annals volume presents a collection of papers stemming from the conference “Malaria 2014: Advances in Pathophysiology, Biology and Drug Development”, April 25, 2014, presented by the Microbiology & Infectious Diseases Discussion Group of the New York Academy of Sciences. The papers discuss recent research on the pathophysiology and biology of malaria and the development of antimalarial drugs, including the molecular basis of antifolate resistance in Plasmodium falciparum; translational regulation during stage transitions in malaria parasites; purine import into malaria parasites as a target for antimalarial drug development; the opportunities for, and challenges of, modeling malaria in humanized mice; the innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin; the pathogenesis of pediatric cerebral malaria; the biology of Plasmodium vivax explored through genomics; and antimalarial drug resistance in Africa.