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Molecular Mechanisms and Models of Aging

Edited by Edited by Efstathios S. Gonos, Ioannis P. Trougakos, and Niki Chondrogianni (National Hellenic Research Foundation, Athens, Greece)
Molecular Mechanisms and Models of Aging

Published: November 2007

Volume 1119

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Aging, an inevitable consequence of life for nearly all organisms, mostly reflects the outcome of complicated interactions among genetic factors along with the accumulation of a variety of deleterious stochastic changes over time. Thus, aging is an adaptive phenomenon, not caused by a single factor or process but a multifactorial process modulated by the interplay among genetic and environmental factors. In the coming years, human aging will be one of the biggest challenges faced by industrialized countries as the average life expectancy is continuously increasing. Several topics are discussed herein, including: replicative senescence, telomeres and telomerase, cancer and aging, DNA repair, free radicals and oxidative stress, proteolysis and proteins maintenance, immunity, neurodegeneration, model organisms, and epidemiological aspects.