Support The World's Smartest Network

Help the New York Academy of Sciences bring late-breaking scientific information about the COVID-19 pandemic to global audiences. Please make a tax-deductible gift today.

This site uses cookies.
Learn more.


This website uses cookies. Some of the cookies we use are essential for parts of the website to operate while others offer you a better browsing experience. You give us your permission to use cookies, by continuing to use our website after you have received the cookie notification. To find out more about cookies on this website and how to change your cookie settings, see our Privacy policy and Terms of Use.

We encourage you to learn more about cookies on our site in our Privacy policy and Terms of Use.


Neural Signaling: Opportunities for Novel Diagnostic Approaches and Therapies

Edited by Edited by Edward J. Goetzl (University of California, San Francisco, California)
Neural Signaling: Opportunities for Novel Diagnostic Approaches and Therapies

Published: November 2008

Volume 1144

Learn More

Low-molecular-weight chemicals produced and secreted by neurons and a limited range of non-neural cells are the major vehicles of communication between nerve cells and other neurally controlled non-neural cells. Research over the past several decades has identified a wide spectrum of such \"neuromediators\", delineated their structures, elucidated pathways of biosynthesis and biodegradation, and determined the processes of development and function that they influence physiologically. These studies have revealed the nature of cellular receptors that recognize neuromediators selectively and the pathways that transduce signals from neuromediator-occupied receptors to the target cells. For most neuromediators and their receptors, pharmacological agonists and antagonists of high specificity also have been discovered or designed and synthesized. This volume examines the conceptual, methodological, and practical progress in the field from broader biological and pathophysiological perspectives.