Many studies have now illustrated the importance of the equilibrium between the interacting immune, nervous, and endocrine systems for integrated physiology and homeostasis, and alterations in this equilibrium are implicated in the pathogenesis of several autoimmune and inflammatory diseases. This Annals volume presents recent research on the communication and regulatory mechanisms integrating the nervous, endocrine, and immune systems in both health and disease. The papers cover a range of topics in neuroimmunomodulation, including inflammation, gastrointestinal physiology, and behavior; inflammatory mediators and chronic pain; metabolic and neuroendocrine disorders in HIV; cytokines/ chemokines in the central and peripheral nervous system; glia and neuroinflammation; therapeutic interventions in neuroimmunological diseases; aging and neuroimmunomodulation; epigenetics, inflammation, and mental health; stress and immunity; and psychiatric disorders and immunity.