Annals

Oligonucleotide Therapeutics (1)

Edited by Edited by John Rossi (Beckman Research Institute of the City of Hope, Duarte, California), Michael Gait (Medical Research Council, Cambridge, UK), and Fritz Eckstein (Max-Planck Institute for Experimental Medicine, Göttingen, Germany)
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Oligonucleotide Therapeutics (1)

Published: September 2009

Volume 1175

This Annals volume presents new technologies in the field of oligonucleotide research by basic researchers in molecular biology, cell biology, nucleic acid chemistry, pharmacology, and applied therapeutics .
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Oligonucleotides modulate gene-specific expression within cells and can be used to identify genes involved in diseases. Continuing developments in oligonucleotide research have begun to unleash their potential as therapeutic agents. This volume focuses on small RNA-mediated gene silencing, micro RNA (miRNA), oligonucleotide chemistry and new technologies, delivery strategies, immunorecognition of nucleic acids, drug and therapeutic development, aptamers and other evolved systems, and preclinical models and clinical programs.