Annals

Parkinson's Disease

Edited by

Edited by Howard J. Federoff (University of Rochester Medical Center, Rochester, New York) and Robert E. Burke and Stanley Fahn (Columbia University, New York, New York)

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Parkinson's Disease

Published: June 2003

Volume 991

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Parkinson's Disease (PD), a progressive neurological disorder arising from degeneration of dopaminergic neurons in the substantia nigra region of the brain, is characterized by impairment of movement control. It progresses from symptoms such as tremor and muscular rigidity to total disability and death. This volume focuses on the dopaminergic system from a developmental perspective, with the objective of improving the understanding of how dopaminergic neurons form, how they mature and respond to genetic and environmental factors, and how they may be regenerated.