The social environment has an enormous influence in altering behavior, neuroendocrine function, immune system activity, and cardiovascular and metabolic function. Improving the social environment has an enormous and unrealized potential for altering brain function and systemic physiology to improve physical and mental health and to prevent or slow the course of disease. The goal of this volume is to advance knowledge of the neural bases underlying both positive and adverse social interactions, the impact of these social experiences on the brain and body, and to open a dialogue between clinicians and basic scientists to improve treatment options for patient populations and intervention strategies for those at risk. The program canvassed a diverse range of topics, from fear conditioning to the implementation of treatment strategies in the workplace, and is designed to closely link advances in animal model systems with human studies. The volume highlights the implications of social experiences and stress on basic neuroscience and physiology, and the potential translational nature of such findings to the clinic and general public.