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Special Issue: Hematopoietic Stem Cells IX

Edited by

Lothar Kanz (University of Tübingen, Tübingen, Germany), Willem E. Fibbe (Leiden University Medical Center, Leiden, the Netherlands), Julia Skokowa (University Hospital Tübingen, Tübingen, Germany), and John E. Dick (University of Toronto, Toronto, Ontario, Canada)

Special Issue: Hematopoietic Stem Cells IX

Published: April 2016

Volume 1370

Published since 1824, Annals of the New York Academy of Sciences is the Academy’s premier scientific publication.

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Stemming from the ninth international symposium “Hematopoietic Stem Cells IX,” held and hosted by the University of Tübingen, Germany in April 2015, this special issue presents 11 commissioned reviews on diverse issues including the molecular landscapes of human hematopoietic stem cells in health and leukemia; mechanisms of mesenchymal stromal cell–mediated immunomodulation through patient monitoring and product characterization; converting cell fates and generating hematopoietic stem cells de novo via transcription factor reprogramming; the functional relationship between hematopoietic stem cells and developing T lymphocytes; regulation of hematopoietic stem cell integrity through p53 and its related factors; niche heterogeneity in the bone marrow; the endothelial-to-hematopoietic transition and notch-ing vessels into blood; isolation and characterization of primary bone marrow mesenchymal stromal cells; and the role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia.