Annals

Special Issue: Tight Junctions and Their Proteins I

Edited by

Michael Fromm, Dorothee Günzel, and Jörg-Dieter Schulzke (Charité, Campus Benjamin Franklin, Berlin, Germany)

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Special Issue: Tight Junctions and Their Proteins I

Published: June 2017

Volume 1397

Published since 1824, Annals of the New York Academy of Sciences is the Academy’s premier scientific publication.

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Tight junctions between epithelial and endothelial cells form selective barriers. However, some tight junction proteins form ion or water channels that conduct through the otherwise sealed barrier between epithelial cells. Owning to this function they regulate paracellular transport of solutes, immune cells, and drugs. In various diseases tight junction proteins can be either up- or downregulated, and by this they aggravate, or even induce, pathogenesis. 

This special issues is the first of two presenting reviews and original research on tight junctions.