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Steroids in Neuroendocrine Immunology and Therapy of Rheumatic Diseases I

Edited by Edited by Maurizio Cutolo (University of Genoa), Rainer H. Straub (University Hospital Regensburg), Alfonse T. Masi (University of Illinois College of Medicine), and Johannes W.J. Bijlsma (University Medical Center Utrecht)
Steroids in Neuroendocrine Immunology and Therapy of Rheumatic Diseases I

Published: May 2014

Volume 1317

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Neuroendocrine immune mechanisms have been shown to be increasingly involved in rheumatic diseases, particularly in chronic immune–inflammatory diseases, suggesting an important role for steroid hormones and the nervous system in their pathogenesis. Recent research in this area was presented at the 5th International Conference on Neuroendocrine Immunology in Rheumatic Diseases, held October 1–3, 2013, in Genova, Italy. Among the topics explored, and a focus of this first of two Annals volumes, were sex hormones and immune–inflammatory reactivity, including aromatase and the regulation of the estrogen-to-androgen ratio in synovial tissue inflammation; the sexually dimorphic actions of glucocorticoids; insufficiency of adrenocortical steroids in premenopausal-onset rheumatoid arthritis (RA); and safety issues of biologics in pregnant patients with RA. Another focus of this volume is the involvement of the vitamin D endocrine system in neuroendocrine immune mechanisms in rheumatic diseases.