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Steroids in Neuroendocrine Immunology and Therapy of Rheumatic Diseases II

Edited by Edited by Maurizio Cutolo (University of Genoa), Rainer H. Straub (University Hospital Regensburg), Alfonse T. Masi (University of Illinois College of Medicine), and Johannes W.J. Bijlsma (University Medical Center Utrecht)
Steroids in Neuroendocrine Immunology and Therapy of Rheumatic Diseases II

Published: May 2014

Volume 1318

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Neuroendocrine immune mechanisms have been shown to be increasingly involved in rheumatic diseases, particularly in chronic immune–inflammatory diseases, suggesting an important role for steroid hormones and the nervous system in their pathogenesis. Recent research in this area was presented at the 5th International Conference on Neuroendocrine Immunology in Rheumatic Diseases, held October 1–3, 2013, in Genova, Italy. Among the topics explored, and a focus of this second of two Annals volumes, were glucocorticoids, including the origin and functions of membrane-bound glucocorticoid receptors; glucocorticoid metabolism in rheumatoid arthritis (RA); the safety of low- to medium-dose glucocorticoid treatment in RA with respect to glucocorticoid toxicity and bone health; international recommendations on the timing and duration of glucocorticoid treatment in RA; glucocorticoids in juvenile idiopathic arthritis; the circadian rhythms that regulate glucocorticoid synthesis and action; and a comparison of chronic inflammatory diseases and chronic psychological stress.