Not only do psychiatric and neurologic disorders result from dysfunction of a single organ, they are also often disorders with significant overlap and comorbidity. The goal of breaking conceptual boundaries between neurology and psychiatry, which have been well articulated by many over the last 25 years, is the basis for The Year in Neurology and Psychiatry, a new annual reviews series. In this first issue, a wide range of important topics are covered, with some topics lying squarely within either neurology or psychiatry, including comprehensive reviews of the most recent advances in stroke prevention, animal models of Parkinson's disease, and postmortem studies supporting the glutamate hypothesis of schizophrenia. Other reviews bridge both fields, such as a review of fragile X tremor/ataxia syndrome, which ties novel mechanisms of RNA aggregation–induced degeneration with neurobehavioral and motor system dysfunction in patients; similarly, the authoritative review on frontotemporal dementia ties motor neuron degeneration to severe behavioral and cognitive disturbances, including adult-onset psychosis and frontal executive dysfunction. Closing the issue is a review on autoimmune encephalopathies, which links immunology, cancer, motor dysfunction, and neuropsychiatry.