Annals

Therapeutic Oligonucleotides (1)

Edited by Edited by Yoon S. Cho-Chung (National Cancer Institute, National Institutes of Health, Bethesda, Maryland), Alan M. Gewirtz (University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania), and Cy Stein (Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York)
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Therapeutic Oligonucleotides (1)

Published: December 2005

Volume 1058

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The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. The focus is on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides. Specific chapters address designing better siRNAs, splice switching oligonucleotides, selective delivery of oligonucleotides, and medicinal drugs by receptor-mediated endocytosis, development of a function overriding siRNA silencing in mammalian cells, transcription factor decoys, and modified oligonucleotide hybridization and genetic insertion.