Annals

Thymosins in Health and Disease (1)

Edited by Edited by Enrico Garaci (University of Rome “Tor Vergata”, Rome, Italy) and Allan L. Goldstein (Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC)
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Thymosins in Health and Disease (1)

Published: May 2010

Volume 1194

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This meeting brought together many of the leading scientists and clinicians working in the field to report on the latest advances in the chemistry, biology, and clinical applications of the thymosins. The use of chemically defined and synthesized molecules, rather than crude or partially purified extracts has enabled scientists working in this field to acquire definitive information on the molecular biology, immunology, and potential clinical applications of this important class of biological response modifiers (BRMs). This volume is a synthesis of the four plenary sessions: on the advances being made in the structure, design, immunology, and molecular biology of thymosin alpha 1 (Tα1), prothymosin alpha (ProTα), and thymosin beta 4 (Tβ4); the role of the thymosins in cardioprotection, neuroplasticity, stem cells, wound healing, inflammation, and angiogenesis; clinical applications of Tα1 and other BRMs; and the current status of translational trials with Tβ4 in areas of wound repair, cardiovascular disease, epidermolysis bullosa, and eye injuries.