Books in the Series:
Neurobiological Basis of Migraine provides focused but broad-ranging coverage on the neurobiological mechanisms of migraine headaches. First, the pathways and networks mediating the headache, underlying physiological mechanisms, characteristics of visceral pain, and concept of dural neurogenic inflammation are introduced. This background paves the way for understanding mechanisms sustaining head pain and photophobia, which are complemented by reviews of pharmacology and recently discovered novel treatments of the migraine headache. These basic chapters are followed by clinical and genetic information about migraine that provide the links to concepts such as cortical spreading depression (CSD), ion channels, transporters, and epilepsy. Exciting recent developments on the migraine mutations discovered and their role in CSD and the role of CSD in aura and trigeminal activation (headache) are also introduced.