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Advances in C-H Activation Chemistry

Advances in C-H Activation Chemistry
Reported by
Benjamin Schroeder

Posted September 15, 2020

Presented By

The New York Academy of Sciences

Over the past 15 years, Carbon-Hydrogen (C-H) bond activation and subsequent functionalization has revolutionized the way organic chemists approach target-oriented synthesis. The ability to target and manipulate specific C-H bonds in molecules allows chemists to efficiently functionalize, and in some cases, repurpose existing drugs.


In this eBriefing, You’ll Learn:

  • Why C-H activation is such an effective tool for synthetic organic chemists.
  • New strategies for C-H activation and the formation of new bonds to carbon and nitrogen.
  • The limitations of C-H activation and why certain C-H bonds are more/less reactive than others.
  • Future directions for C-H activation chemistry.


Melanie Sanford, PhD
Melanie Sanford, PhD

University of Michigan

Igor Larrosa, PhD
Igor Larrosa, PhD

The University of Manchester

Synthetic Shortcuts: Advances in C-H Activation Chemistry


Melanie Sanford (University of Michigan)

Melanie Sanford, PhD
University of Michigan   

Melanie Sanford is the Moses Gomberg Distinguished University Professor of Chemistry and Arthur F. Thurnau Professor of Chemistry at the University of Michigan.  She studied C–F bond functionalization with Professor Bob Crabtree during her undergraduate education at Yale University, and worked on metal-catalyzed olefin metathesis reactions with Nobel Laureate Bob Grubbs at Caltech for her PhD.  She moved to the University of Michigan in the summer of 2003 after an NIH-postdoctoral fellowship at Princeton University with Jay Groves.  Her current research focuses on catalytic transformations of organic molecules using organometallic complexes.

Igor Larrosa (The University of Manchester)

Igor Larrosa, PhD
The University of Manchester

Igor Larrosa is a Professor of Organic Chemistry at The University of Manchester.  He grew up in Spain and received his undergraduate and graduate education at the Universitat de Barcelona.  There he worked with Felix Urpi and Pere Romea during his graduate studies and then went on to do two separate postdoctoral research stints with Erick Carreira at ETH Zurich, and then Anthony G. M. Barrett at Imperial College London.  He moved to Manchester in 2014 after rising to the rank of Reader at Queen Mary University of London.  His current research focuses on transition metal catalysis in C–H activation.

Further Readings


Brigham C, Malapit C, Lalloo N, Sanford, M.S.

ACS Catalysis. 2020;10: 8315-8320

Malapit CA, Borrell M, Milbauer MW, et al

J Am Chem Soc. 2020;142,5918-5923

Malapit, C. A.; Bour, J. R.; Brigham, C. E.; Sanford, M. S

Nature. 2018; 563, 100-104


Wang, G.-W.; Wheatley, M.; Simonetti, M.; Cannas, D.M.; Larrosa, I

Chem. 2020;6

Spencer, A.R.A; Korde, R.; Font, M.; Larrosa, I

Chem Sci. 2020;11:4204-4208

Simonetti, M.; Kuniyil, R.; Macgregor, S.A.; Larrosa, I

J Am Chem Soc. 2018;140:11836-11847

Font, M.; Spencer, A.R.A; Larrosa, I

Chem Sci. 2018. 9:7133-7137