The New York Academy of Sciences
Advances in Pulmonary Fibrosis: Beyond the Fibroblast
Posted May 28, 2020
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with few treatment options. Research on IPF and other interstitial lung diseases has historically focused on fibroblasts and the importance of TGF-beta-driven epithelial to mesenchymal transition. Recently, new data have highlighted key roles for additional cell types, including alveolar epithelial cells and endothelial cells, in the development or maintenance of lung fibrosis. Moreover, cellular senescence and immune pathways have also been found to contribute to IPF pathogenesis. This eBriefing showcases emerging biological mechanisms underlying the etiology of pulmonary fibrosis and explores novel ways to remove, repair or regenerate damaged lung.
In This eBriefing, You’ll Learn
- The importance of cellular senescence and immune signaling in IPF
- The roles of endothelial cells and alveolar epithelial cells, which are emerging as key drivers of disease