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Immune-Stromal Cell Interactions in Fibrosis, Cancer, and Beyond

Immune-Stromal Cell Interactions in Fibrosis, Cancer, and Beyond
Reported by
Sara Donnelly

Posted September 09, 2020

Presented By

Biochemical Pharmacology Discussion Group

The New York Academy of Sciences

The stromal microenvironment plays critical roles in tissue homeostasis, wound healing and the inflammatory response. Comprised of fibroblasts, the extracellular matrix, endothelial cells, pericytes, and adipocytes — many elements of the stroma have recently been implicated as important modulators of the shape and intensity of local immune responses. Thus, greater knowledge of the interactions between immune cells and stromal components is critical to understand their roles in both normal and pathological scenarios.

This eBriefing contains the proceeding of the virtual symposium Immune-Stromal Cell Interactions in Wound Healing, Fibrosis and Cancer, which took place on June 9, 2020. The meeting featured discussion of the common mechanisms of reciprocal regulation between stromal constituents and immune cells that may present exciting new therapeutic targets for a variety of diseases including cancer, fibrosis and chronic inflammatory and autoimmune conditions.

In this eBriefing, You’ll Learn:

  • The importance of immune-stromal interactions in both healthy and diseased tissues
  • Key mechanisms governing reciprocal interactions between immune cells and stromal constituents
  • Potential therapeutic targets that present new opportunities for the development of effective drugs for widespread human diseases
Key Role for Cancer-Associated Fibroblasts
Macrophage-Dependent Signaling in Autoimmune Diseases and Fibrosis
Tissue Regeneration and Type II Immune Responses in Inflammation
New Tools for Probing the Molecular Basis of Disease