Immune Memory in Action: Modeling Affinity Maturation
Posted March 30, 2007
The random nature and magnitude of clonal selection provides computational biology and bioinformatics with rich prospects for illuminating fundamental conundrums in immunology. Drawing on experimental work in immune system biodynamics, Steven Kleinstein of Yale University School of Medicine offered a new perspective on the lymphocyte learning process known as affinity maturation.
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Steven H. Kleinstein, PhD
Steven Kleinstein is an assistant professor of pathology at the Yale University School of Medicine. The focus of his research is the development and application of computational methods that leverage mathematical/statistical models and numerical simulations to improve understanding of experimental and clinical data. Detailing the immune response is a particular focus of his work. Kleinstein received his PhD in computer science from Princeton University in 2002.
John Galbraith Simmons
John Galbraith Simmons is a nonfiction author, novelist, and journalist who writes about science and medicine for popular and professional audiences. He is the author of The Scientific 100, which profiles one hundred of the most influential scientists in history, and Doctors and Discoveries: Lives that Created Today's Medicine.