New York Academy of Sciences
Posted January 04, 2007
Blood and urine samples are the basis for over 90% of routine medical tests performed today. But as the use of diagnostic tests proliferates, there is an increasing call for less invasive procedures in clinical practice. Oral-based diagnostics are a leading alternative, and their use has expanded rapidly over the last decade.
The New York Academy of Sciences played a catalytic role in the development of the current generation of saliva-based diagnostics through a conference on the subject in 1993. The second conference was held October 10–13, 2006, at the Emerald Pointe Resort, near Atlanta, Georgia.
This meeting featured presentations from basic researchers, clinicians, informatics specialists, device engineers, and entrepreneurs who can shape the science behind oral-based diagnostics into viable market products, and was designed to promote communication and integration of the various communities in the development to move findings in basic research into applications of clinical diagnostics.
National Institute of Dental and Craniofacial Research (NIDCR)
NIDCR is the National Institutes of Health lead institute in developing oral-based diagnostics.
Pathway to Product Development
Summarizes the goals, challenges, recommendations, and implementation strategies NIDCR is taking to advance development of oral-based diagnostics.
Development and Validation of Technologies for Saliva-Based Diagnostics
The NIDCR funding application describes what the agency is looking for in terms of research objectives.
Workshop on Development of New Technologies for Saliva and Other Oral Fluid-Based Diagnostics
The 1999 report by NIDCR (PDF, 78 KB).
Salivary Proteome Knowledge Base
Database being developed by the Human Salivary Proteome Project. Login required.
The Scripps Research Institute: Saliva Proteome Project
Founded by NIDCR to catalog and annotate the components of saliva.
Sjögren's International Collaborative Clinical Alliance
A worldwide group of clinical and laboratory researchers working to develop the International Sjögren's Syndrome Registry.
UCLA Collaborative Oral Fluid Diagnostic Research Center
The center is working to develop micro- and nano-electrical-mechanical systems (MEMS and NEMS) for the detection of salivary diagnostic analytes for point-of-care applications.
UCLA Human Salivary Proteome Project
A multi-institute, interdisciplinary effort to generate a complete catalogue of all salivary secretory proteins using high-throughput proteomic technologies.
UCLA: Micro/Nanoelectromechanical Systems (MEMS/NEMS) Presentation 1
UCLA: Micro/Nanoelectromechanical Systems (MEMS/NEMS) Presentation 2
PowerPoint presentations on how microchip technology has been used to diagnose oral cancer in saliva.
University of Texas, Austin: McDevitt Research Laboratory
Information about lab-on-a-chip sensor technology; includes description of saliva diagnostics funded by NIDCR.
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Daniel Malamud, PhD
Daniel Malamud is currently professor at the New York University department of basic science and craniofacial biology. He is also the director of the HIV/AIDS research program. Malamud specializes in the development of anti-HIV agents and oral-based diagnostics; his research deals with HIV pathogenesis, the design of anti-HIV drugs, and novel diagnostics using oral samples. His investigations in these areas have involved human salivary proteins that inhibit HIV infectivity and the discovery and development of anti-HIV compounds that can be used to prevent HIV infection in women.
Malamud received his PhD from the University of Cincinnati. After completing his postdoctoral training at the Temple University Medical School department of pathology, he worked at Harvard Medical School and the Massachusetts General Hospital. He then moved to the University of Pennsylvania School of Dental Medicine as associate professor and went on to become chairman of the Department of Biochemistry, before joining the faculty of NYU. Malamud has received the Research Career Development Award, the Basic Science Teaching Award, and the University of Pennsylvania Lindback Teaching Award. He has served as Penn-Israel exchange scientist and as consultant for the French Ministry for External Relations.
R. Sam Niedbala, PhD
R. Sam Niedbala is professor of practice at the Lehigh University Department of Chemistry. He is interested in exploring technologies useful for developing applications in human clinical medicine and is currently developing proteins to allow specific targeting of biological markers of interest. As needed, required software is also developed to facilitate these tasks. Recent projects involve developing detection methods for new biological markers in human oral fluids to detect drugs and infectious diseases.
Niedbala received his PhD in chemistry from Lehigh University. He is the former chief science officer and a founder of OraSure Technologies, Inc. (OTI), which is a publicly traded diagnostic company that develops, manufactures, and markets proprietary diagnostic products capable of detecting substances in a number of different body fluids, including saliva. Niedbala holds professional memberships in the American Association for Clinical Chemistry, American Chemical Society, Society of Forensic Toxicologists, and The American College of Forensic Examiners. He holds numerous patents and over forty peer-reviewed articles and book chapters in numerous areas of technology and medicine.
Quest Diagnostics Incorporated
William R. Abrams, PhD
Arie V. Nieuw Amerongen, PhD
Per Brandtzaeg, DDS, PhD
C. Sue Carter, PhD
James Clarke, PhD
International Diagnostic Systems Corp
Edward J. Cone, PhD
Paul C. Denny, PhD
Philip C. Fox, DDS
Elain Fu, PhD
Vincent Gau, PhD
Michael Glick, DMD
Douglas Granger, PhD
John S. Greenspan, PhD
Marilyn A. Huestis, PhD
David R. Jacobs, Jr., PhD
William G. Kohn, DDS
Ira Lamster, DDS
Loralie J. Langman, PhD
Antoon J. M. Ligtenberg, PhD
Jeffrey A. Lindeman, PhD
Duncan A. MacKellar
Andreas Manns, PhD
John T. McDevitt, PhD
James E. Melvin, DDS, PhD
Frank Oppenheim, DMD, PhD
George Preti, PhD
Christoph Ramseier, DMD
Miriam P. Rosin, PhD
Anup Singh, PhD
Steven L. Spitalnik, MD
E. Michelle Starke, PhD
Lawrence A. Tabak, DDS, PhD
H. J. Tanke, PhD
David Walt, PhD
David Wong, DMD, DMSc
Netty D. Zegers, PhD
Bob Roehr is a biomedical writer with a focus on HIV and infectious disease who is based in Washington, DC.