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Skeletal Development and Remodeling in Health, Disease, and Aging

Skeletal Development and Remodeling in Health, Disease, and Aging

Wednesday, May 18, 2005 - Saturday, May 21, 2005

Mount Sinai School of Medicine

Presented By

Presented by the New York Academy of Sciences and Mount Sinai School of Medicine


Our understanding of how the skeleton is remodeled and repaired has been vastly expanded in the past decade. Using advanced molecular technologies, including transgenesis, gene knockout, and gene array, we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have helped us understand not only the basic biological properties of the skeleton and how it responds to hormonal, cytokine, and mechanical stimulation, but have also, in some instances, helped clarify the source of the pathophysiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development.

Our goal for this conference is to facilitate increased understanding in the scientific community and to encourage scientific leaders to share current information, to derive consensus, and to disseminate crystallized ideas in a coordinated and authoritative fashion. The conference is divided into four broad themes: skeletal development and repair, molecular endocrinology of bone, bone cell biology, and conservation of skeletal integrity. Participants will be able to engage in a focused discussion within each category. The final day will specifically focus on current and emerging therapies for osteoporosis.

Scientific Director and Chair:

Mone Zaidi (Mount Sinai School of Medicine)

Solomon Epstein (Mount Sinai School of Medicine)
Steven L. Teitelbaum (Washington University School of Medicine)

Keynote Speakers:

  • Harvey V. Fineberg (Institute of Medicine of the National Academies)
  • Henry Kronenberg (Massachusetts General Hospital & Harvard Medical School)
  • David L. Lacey (Amgen, Inc.)
  • Bjorn Olsen (Harvard Medical School)
  • Dame Julia Polak (Imperial College)
  • Graham Russell (University of Oxford)
  • Allen M. Spiegel (NIDDK, National Institutes of Health)
  • Steven L. Teitelbaum (Washington University School of Medicine)