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Bisphosphonates and Osteonecrosis of the Jaw

Bisphosphonates and Osteonecrosis of the Jaw

Saturday, May 19, 2007

The New York Academy of Sciences

Presented By

Presented by College of Physicians and Surgeons of Columbia University, Columbia University College of Dental Medicine, and the New York Academy of Sciences


Program Description

In the last several years, reports of patients treated with bisphosphonates (primarily those delivered intravenously) have emerged associating their use with osteonecrosis of the jaw (ONJ). More than a thousand cases of bisphosphonate-associated ONJ have been identified since the first cases were reported in 2001. In these, ONJ rarely occurs "spontaneously"; the vast majority have been associated as a consequence to oral surgical procedures. Although most of the reports of ONJ have occurred in patients following the use of high dose IV therapy for metastatic bone disease, there are also reports of ONJ in patients taking oral bisphosphonates. Since millions of patients take oral bisphosphonates for the treatment of osteoporosis, it is timely to review what is known and needs to be learned about this emerging issue in patient care—to develop a consensus on the definition of ONJ, as well as to explore potential risk factors and pathogenic mechanisms of ONJ and to explore strategies to move research forward. This conference is designed to facilitate multidisciplinary collaboration. Physicians, dentists, basic, clinical and translational investigators, health care organization administrators and all healthcare professionals are urged to attend.

Learning Objectives

At the end of this course participants should: 1) Improve their awareness of the condition of ONJ; 2) Understand the need for increased screening and improved diagnosis of ONJ; 3) Appreciate the treatment options for ONJ; 4) Be able to discuss and help guide future areas for research; and 5) Appreciate the mulitidisciplinary nature of ONJ related to both research activities and patient care.

Scientific Organizing Committee

  • John P. Bilezikian, MD, Columbia University College of Physicians and Surgeons (Course Director)
  • John T. Grbic, DDS, MMSc, Columbia University College of Dental Medicine (Course Director)
  • G. David Roodman, MD, PhD, University of Pittsburgh Hillman Cancer Center
  • Catherine H. Van Poznak, MD, University of Michigan Comprehensive Cancer Center

Continuing Education Information

Accreditation /Credit Designation: This program has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the College of Physicians and Surgeons of Columbia University, Columbia University College of Dental Medicine and The New York Academy of Sciences. The College of Physicians and Surgeons of Columbia University is accredited by the ACCME to provide continuing medical education for physicians. The College of Physicians and Surgeons designates this educational a

This program is partially supported by educational grants from Merck & Co., Inc., Novartis and The Alliance for Better Bone Health (Procter & Gamble Pharmaceuticals and Sanofi-Aventis U.S. LLC).

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