
Journal of Cell Biology Meeting, Cell Biology of Disease
Wednesday, September 23, 2009 - Friday, September 25, 2009
This 2.5-day conference will address recent advances in our understanding of disease pathology at the cellular and molecular level, with a focus on cancer. Presenters will discuss diseases caused by chromosomal abnormalities, DNA repair mechanism defects, and other nuclear irregularities. The meeting will also highlight progress in stem cell research with a focus on its application to cancer and diseases. The symposium will focus on basic science, but will provide some integration with subsequent clinical applications so that bench researchers and clinicians can develop a mutual understanding of the potential for translation of basic research into effective therapeutics.
Presented by:
For a complete list of sponsors, please click the Sponsorship tab.
Agenda
*Presentation times are subject to change.
Day 1: Wednesday, September 23, 2009 | |
4:00 PM | Registration and Poster Session Set-Up |
5:00 PM | Opening Remarks |
Keynote Lectures | |
5:15 PM | New Dimensions in Cell Migration and Matrix Interactions |
6:00 PM | Rho GTPase Signaling in Migration and Morphogenesis |
6:45 PM | Reception and Poster Viewing |
Day 2: Thursday, September 24, 2009 | |
8:00 AM | Registration |
Session I: Stem CellsChair: Elaine Fuchs, PhD, Rockefeller University | |
9:00 AM | Stem Cells in the Skin: The Privileged Few |
9:45 AM | Epigenomics and Cellular States |
10:15 AM | Coffee Break |
10:45 AM | Stem Cells and their Niche in the Adult Mammalian Brain |
11:15 AM | Evolutionary Conserved Aging and in Rejuvenation of Organ Stem Cells Between Mice and Humans |
11:45 AM | Chromatin Regulation in Drosophila Stem Cells and Their Daughters |
12:15 PM | Lunch and Poster Session |
Session II: ChromosomesChair: Rebecca Heald, PhD, University of California, Berkeley | |
2:00 PM | Using Xenopus Egg Extracts to Investigate Mitotic Chromosome Dynamics and Mechanisms of Intracellular Scaling |
2:45 PM | Generating a Dynamic Kinetochore-Microtubule Interface |
3:15 PM | Coffee Break |
3:45 PM | Examining Cell Division Mechanisms Using Chemical Biology Approaches |
4:15 PM | Polyploidy, Aneuploidy & Genome Stability |
4:45 PM | DNA Repair and Transcription in Living Tissue |
5:15 PM | Conclusion of Day 2 |
Day 3: Friday, September 25, 2009 | |
8:00 AM | Registration |
Session III: CancerChair: Ira Mellman, PhD, Genentech, Inc. | |
9:00 AM | Cell Biology and Cancer, In Translation |
9:45 AM | The Cell Biology of PTEN/AKT Regulation in Cancer |
10:15 AM | Coffee Break |
10:45 AM | Role of Shelterin in Cancer and Aging |
11:15 AM | Cell Polarity Pathways as Regulators or Morphogenesis and Tumorigenesis |
11:45 AM | Invadopodia, Specialized Cell Structures for Cancer Invasion |
12:15 PM | Lunch and Poster Viewing |
12:30 PM | Career Session (Break-out room) |
Closing Keynotes | |
2:00 PM | Guarding the Genome: Centromeres, Aneuploidy, and Tumorigenesis |
2:45 PM | Small RNA Mediated Epigenetic Mechanism in Stem Cell Self-Renewal |
3:30 PM | Deconstructing Metastasis |
4:15 PM | Closing Remarks |
4:30 PM | Conclusion of Conference |
Organizers
Rebecca Heald, PhD
University of California, Berkeley
Emma Hill, PhD
The Journal of Cell Biology, Rockefeller University Press
Tom Misteli, PhD
The Journal of Cell Biology, Rockefeller University Press
Kathy Granger, PhD
The New York Academy of Sciences
Keynote Speakers
Don W. Cleveland, PhD
Ludwig Institute for Cancer Research
Elaine Fuchs, PhD
Rockefeller University
Alan Hall, PhD
Memorial Sloan-Kettering Cancer Center
Haifan Lin, PhD
Yale University
Joan Massague, PhD
Memorial Sloan-Ketting Cancer Center
Ira Mellman, PhD
Genentech, Inc.
Kenneth Yamada, MD, PhD
National Institutes of Health
Speakers
Maria A.Blasco, PhD
Spanish National Cancer Center (CNIO)
Michael Buszczak, PhD
University of Texas Southwestern Medical Center
Iain Cheeseman, PhD
Massachusetts Institute of Technology
Irina Conboy, PhD
University of California, Berkley
Fiona Doetsch, PhD
Columbia University
Tarun Kapoor, PhD
Rockefeller University
Alexander Meissner, PhD
Harvard University
Senthil Muthuswamy, PhD
Ontario Cancer Institute
David S. Pellman, MD
Dana Farber Cancer Institute
Lloyd Christopher Trotman, PhD
Cold Spring Harbor Laboratory
Wim Vermeulen, PhD
Erasmus MB
Alissa Weaver, MD, PhD
Vanderbilt University Medical Center
Sponsors
For sponsorship opportunities please contact Sonya Dougal at sdougal@nyas.org or 212.298.8682.
Presented by
Academy Friends
- Genentech, Inc.
- Hamamatsu Corporation
- Hoffmann-La Roche
- Promega Corporation
- Sutter Instrument Company
The project described is supported by Award Number R13CA141983 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.
Media Partners
- American Society of Gene & Cell Therapy
- Hybrodima
- International Society for Stem Cell Research
- The Journal of Cell Biology
- The Journal of Experimental Medicine
- The Journal of General Physiology
- The Lancet
- Nature
Day 1: Wednesday, September 23
Keynote Lectures
New Dimensions in Cell Migration and Matrix Interactions
Kenneth M Yamada, MD, PhD1, Andrew D Doyle, PhD1, Tomohiro Onodera, MD, PhD1, Takayoshi Sakai, DDS, PhD1,2, Jeff Chi-feng Hsu, PhD1 , Vira V Artym, PhD1,3 , and Kazue Matsumoto1
1Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland; 2Depertment of Oral-Facial Disorders, Osaka University Graduate School of Dentistry, Osaka, Japan; 3Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Washington DC
Cells migrate, tumors invade, and tissues remodel in three-dimensional (3D) environments. However, most mechanistic studies in cell biology are conducted using traditional tissue culture on flat, two-dimensional (2D) substrates. Recent studies from a number of laboratories show that many fundamental biological properties of cells are governed by dimensionality and other physical properties of the local environment. Cells interacting with extracellular matrices that are 2D versus 3D differ in cell morphology, signaling, modes of migration, and requirements for cell-surface integrins and proteases. Another notable feature of 3D matrices in vivo is that many are fibrillar rather than flat or uniform in texture. Interestingly, "1D" fibrillar lines on a flat surface can mimic many of the properties of a cell-derived 3D fibrillar matrix in terms of cell morphology, migration mode, and even Golgi and centrosome orientation. The requirement for proteases in tumor cell invasion can also differ depending on the type of matrix. These studies emphasize the importance of choosing one's model system carefully, because mechanistic conclusions can differ significantly depending upon dimensionality and other physical properties. In fact, for some studies, a 1D system can provide more accurate physiological insights into 3D biology than regular 2D tissue culture.
The spatial arrangement and dynamics of 3D cell and tissue movements are particularly important in tissue remodeling processes involved in embryonic development, cancer, and tissue engineering. 3D culture and direct imaging of cells undergoing tissue remodeling in organ formation have revealed roles for integrins, fibronectin, and cell motility. Organ morphogenesis, as well as 3D in vitro reconstitution of the initial steps of this process starting from single cells, involves cell-surface interactions dependent on integrins, E-cadherin, and dramatic epithelial cell movements. The mechanisms that lead from undifferentiated, amorphous collections of cells to a complex branched structure in organ development involve cell-matrix interaction, novel regulatory molecules such as Cleftin, and coordinated effects on cell-cell and cell-matrix adhesion systems associated with transient epithelial cell motility. These applications of 3D model systems, combined with live-tissue imaging, should continue to provide new insights into the mechanisms of cell migration, invasion, and tissue remodeling.
Rho GTPase Signaling in Migration and Morphogenesis
Alan Hall1, Joanne Durgan1, Aron Jaffe1,2 and Noriko Kaji1. 1Memorial Sloan-Kettering Cancer Center, Cell Biology Program, 1275 York Avenue, New York, NY 10065. 2Current address: Novartis Institutes for Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA
Rho family GTPases control signal transduction pathways that regulate the assembly and spatial organization of the actin cytoskeleton and associated cell-matrix and cell-cell adhesion complexes. Rho regulates contractile actin:myosin filament and focal adhesion assembly, Rac regulates the formation of membrane protrusions (lamellipodia), while Cdc42 triggers filopodial extensions at the cell periphery. In addition, Rho GTPases promote a diverse set of other cellular activities, including changes in gene transcription, the establishment of cell polarity, cell cycle progression, the organization and dynamics of the microtubule cytoskeleton and the activation of a variety of enzymes including PI 3-kinase and NADPH oxidases. The actin and microtubule cytoskeletons play a central role in driving many of the dynamic aspects of cell behavior and our particular focus is to determine the molecular mechanisms by which Rho GTPases regulate cell migration and cell morphogenesis. The disruption of normal tissue architecture and the appearance of inappropriate migratory activity are two defining characteristics associated with cancer progression towards an invasive and metastatic phenotype. Our long-term goal is to identify the mechanisms that drive these changes.
Travel & Lodging
Our Location
The New York Academy of Sciences
7 World Trade Center
250 Greenwich Street, 40th floor
New York, NY 10007-2157
212.298.8600
Hotels Near 7 World Trade Center
Recommended partner hotel:
52 William Street (Between Wall & Pine Streets)
New York, NY 10005
Phone: (212) 269-6400
Located in the center of historical New York, Club Quarters, at 52 William Street (between Pine & Wall Streets), is just a short walk to our location. The New York Academy of Sciences is a part of the Club Quarters network. Please feel free to make accommodations on-line to save significantly on hotel costs.
Password: NYAS
Other hotels located near 7 WTC:
212.945.0100 |
212.693.2001 |
212.385.4900 |
212.766.6600 |
212.742.0003 |
212.232.7700 |
212.747.1500 |
212.344.0800 |