Lyceum Society: Current Theories of Aging, Part II
Thursday, March 19, 2009
The Lyceum Society is comprised of the Academy's retired and semi-retired members, but any Academy member is welcome. Talks cover various scientific fields.
All Lyceum meetings (except December) are Brown Bag lunches.
Brown Bag: 11:30 am; Lecture & Discussion: 1pm to 3 pm.
In 2006 Craig Mellow and Andrew Fire received the Nobel Prize for their work on RNA inhibition. After publication of their historic paper in 1998, the field of "gene silencing" exploded. Increased understanding of the action of genes in development, disease, and therapy followed.
In Part I of "Current Theories of Aging," presented March 20, 2008, we learned that aging involves changes in gene expression. The role of epigenetics in aging was introduced, and we explored one method of gene silencing that occurs during transcription, namely, histone methylation.
In Part II we will explore another mechanism involved in regulating gene expression that occurs during translation, namely, the repression or degradation of messenger RNA by microRNAs. Aspects of Part I and the role of RNA in protein synthesis will be reviewed, followed by a discussion of microRNA, its history, biosynthesis, and role in development, pathology, therapeutic interventions, and aging.
See: NYTimes: Science Times. Beyond the Gene. 11/11/08; pp. D1-D5
Dr. Arline Cohn is Professor Emeritus of Biology at York College, CUNY (immunology, histology, anatomy & physiology, biology of aging). Her MA (Physiology) is from Hunter College and her PhD (anatomy) is from Downstate Medical Center, SUNY, 1971.
Her many honors include awards from Rockefeller University and a Presidential Research Award from York College. She has been consultant for several NIH programs, such as the Experimental Immunology Study Section. She has authored or co-authored uncountable articles in publications such as the J. Immunological Methods, Clinical Exper. Immunology, Arthritis and Rheumatism, Immunology Today, etc. Research for most of these papers supported by CUNY, PSC, and NIH.