FREE
for Members
A Chemical Biology Approach to Epigenetics
Monday, January 25, 2010
The Chemical Biology Discussion Group brings together chemists and biologists interested in learning about the latest ideas in this rapidly growing field. It provides a forum for lively discussion and for establishing collaborations between chemists armed with novel technologies and biologists receptive to using these approaches to solve their chosen biological problems. Post-docs from the chemical biology community in the New York area have organized this special meeting.
Agenda
The Enzymatic Activity of Sirtuins: Beyond NAD-Dependent Deacetylation
Hening Lin, Cornell University
Sirtuins, NAD and Dietary Restriction Combine to Modulate Epigenetic States, Gene Expression and Protein Activity
Anthony Sauve, Weill Cornell Medical College
Molecular Recognition of the Nucleosome
Song Tan, Penn State
Networking Reception to Follow
Organizers
Yana Cen
Weill Cornell Medical College
Danielle Guarracino
New York University
Carl Machutta
GlaxoSmithKline
Sofia B. Rodriguez
Albert Einstein College of Medicine
Zhongping Tan
Memorial Sloan-Kettering Cancer Center
Speakers
Hening Lin
Cornell University
Hening Lin is currently Assistant Professor in the Department of Chemistry and Chemical Biology at Cornell University. He was a postdoctoral fellow in the Christopher Walsh lab at Harvard Medical School. He received his BS in Chemistry from Tsinghua University, Beijing, China and his PhD in Bioorganic Chemistry from Columbia University.
Anthony Sauve
Weill Cornell Medical College
Anthony A Sauve was born in Los Angeles. He attended UC Berkeley and received a BA in Biochemistry. He received his PhD in Chemistry from Princeton University. He was an NIH post-doctoral fellow in the laboratory of Professor Vern L Schramm at Albert Einstein College of Medicine in the Bronx. He is currently an Associate Professor of Pharmacology at Weill Medical College of Cornell University. Dr Sauve has been an influential contributer to understanding the enzymology of ADP-ribosylating enzymes and has published numerous papers in the sirtuin and NAD field. He has been a member of the Scientfic Advisory Board of Sirtris Pharmaceuticals since 2005.
Song Tan
Penn State University
Song Tan is Associate Professor of Biochemistry and Molecular Biology at Penn State University. He received his BS in Physics from Cornell University, and his PhD in Molecular Biology from the University of Cambridge. As a postdoc and a project leader in Tim Richmond's laboratory at the ETH-Zurich in Switzerland, he determined crystal structures of multicomponent protein-DNA complexes. The Tan laboratory uses biochemical and structural methods, including X-ray crystallography, to understand how chromatin factors and enzymes recognize their nucleosome substrate.
Abstracts
The Enzymatic Activity of Sirtuins: Beyond NAD-Dependent Deacetylation
Hening Lin, Cornell University
Sirtuins have been recognized as NAD-dependent deacetylases that regulate important biological processes, including life span, transcription, cell survival, and metabolism. Mammals have 7 sirtuins, SIRT1-7. Of the seven human sirtuins, only three of them, SIRT1, SIRT2, and SIRT3, have robust deacetylation activities in vitro and in vivo. The other sirtuins either have no detectable or very weak deacetylation activity in vitro. I will present our work demonstrating that sirtuins with no or very weak deacetylation activity have other enzymatic activities that may regulate transcription and other biological processes.
Sirtuins, NAD and Dietary Restriction Combine to Modulate Epigenetic States, Gene Expression and Protein Activity
Anthony Sauve, Weill Cornell Medical College
Sirtuins are biologically conserved protein deacetylases that react NAD with histones and other proteins, such as transcription factors and enzymes, thus regulating diverse biological processes. Sirtuin enzymes are highly responsive to changes induced by dietary restriction and appear to mediate a number of potent biological effects attributed to reduced calorie intake, such as increased lifespan. This seminar will explore how nature uses the highly conserved catalytic site of sirtuins to accomplish lysine deacetylation. In addition, studies to determine how sirtuin activities are linked to dietary restriction will be examined.
Molecular Recognition of the Nucleosome
Song Tan, Penn State University
Although we have a reasonable understanding of how proteins bind to DNA, we lack an equivalent understanding of how chromatin enzymes and factors interact with chromatin. My laboratory is investigating how the chromatin factor RCC1 (regulator of chromosomal condensation) interacts with the nucleosome to regulate mitosis, nucleocytoplasmic transport and nuclear envelope dynamics. Our biochemical studies and our crystal structure of the 300 kD RCC1/nucleosome core particle complex show us for the first time the molecular details of how a chromatin factor recognizes the nucleosome.
Travel & Lodging
Our Location
The New York Academy of Sciences
7 World Trade Center
250 Greenwich Street, 40th floor
New York, NY 10007-2157
212.298.8600
Hotels Near 7 World Trade Center
Recommended partner hotel:
Club Quarters, World Trade Center
140 Washington Street
New York, NY 10006
Phone: (212) 577-1133
Located on the south side of the World Trade Center, opposite Memorial Plaza, Club Quarters, 140 Washington Street, is just a short walk to our location. The New York Academy of Sciences is a part of the Club Quarters network. Please feel free to make accommodations on-line to save significantly on hotel costs.
Password: NYAS
Other hotels located near 7 WTC:
212.945.0100 |
212.693.2001 |
212.385.4900 |
212.693.2001 |
212.269.6400 |
212.742.0003 |
212.232.7700 |
212.747.1500 |
212.344.0800 |